Obana A, Miki T, Hayashi K, Takeda M, Kawamura A, Mutoh T, Harino S, Fukushima I, Komatsu H, Takaku Y
Department of Ophthalmology, Osaka City University Medical School, Japan.
Am J Ophthalmol. 1994 Dec 15;118(6):749-53. doi: 10.1016/s0002-9394(14)72554-1.
We evaluated the safety of indocyanine green for use in fundus angiography.
We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus camera.
Ophthalmologists at 15 institutions responded, reporting a total of 3,774 indocyanine green angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous indocyanine green testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of indocyanine green used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock.
A comparison of frequency of adverse reactions to indocyanine green with the previously reported frequency of such reactions to fluorescein sodium indicated that indocyanine green is a safe as fluorescein for use in angiography.
我们评估了吲哚菁绿用于眼底血管造影的安全性。
我们向日本的32家机构发送了一份关于吲哚菁绿并发症的调查问卷，这些机构是根据生产吲哚菁绿眼底相机的拓普康公司的客户名单挑选出来的。
15家机构的眼科医生做出了回应，报告在1984年6月至1992年9月期间对2820例患者共进行了3774次吲哚菁绿血管造影。在血管造影前，15家机构中的13家进行了皮内或静脉注射吲哚菁绿试验，或两者都进行了。对于3例患者，在血管造影前试验呈阳性后决定不进行血管造影。用于血管造影的吲哚菁绿剂量因机构而异，从25毫克到75毫克不等。有13例不良反应（0.34%），其中10例为轻度反应，如恶心、皮疹、荨麻疹、瘙痒和便意，无需治疗。还记录了1例静脉疼痛，需要治疗，以及2例低血压。这2例低血压患者需要抗休克治疗。
将吲哚菁绿不良反应的发生率与先前报道的荧光素钠不良反应发生率进行比较表明，吲哚菁绿在血管造影中与荧光素一样安全。
