美国原住民中的黑棘皮病：糖尿病高风险的一个指标。
Acanthosis Nigricans among Native Americans: an indicator of high diabetes risk.
作者信息
Stuart C A, Smith M M, Gilkison C R, Shaheb S, Stahn R M
机构信息
Department of Internal Medicine, University of Texas Medical Branch at Galveston 77555-1060.
出版信息
Am J Public Health. 1994 Nov;84(11):1839-42. doi: 10.2105/ajph.84.11.1839.
Abstract
Prevalence of the skin lesion acanthosis nigricans was determined in two tribal communities in Texas and Nebraska. Thirty-eight percent of the Alabama-Coushatta tribe of Texas had acanthosis nigricans. Nineteen percent of Omaha and Winnebago tribal children had the skin lesion; the youngest children had the least acanthosis nigricans. Among weight-matched Alabama-Coushatta, fasting insulin concentrations were twofold higher in subjects with the lesion. It was concluded that acanthosis nigricans is highly prevalent among Native Americans and that its presence suggests insulin resistance. Thus, it may identify those with the highest risk for non-insulin-dependent diabetes mellitus in this population.
摘要
在得克萨斯州和内布拉斯加州的两个部落社区中，对黑棘皮病这种皮肤病变的患病率进行了测定。得克萨斯州的阿拉巴马 - 库沙塔部落中有38%的人患有黑棘皮病。奥马哈和温内巴戈部落的儿童中有19%患有这种皮肤病变；年龄最小的儿童黑棘皮病发病率最低。在体重匹配的阿拉巴马 - 库沙塔部落人群中，患有该病变的受试者空腹胰岛素浓度高出两倍。得出的结论是，黑棘皮病在美洲原住民中非常普遍，其存在表明存在胰岛素抵抗。因此，它可能识别出该人群中患非胰岛素依赖型糖尿病风险最高的人。
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