Colombo P L, Todde A, Belisomo M, Bianchi C, Sciutto A M, Tinozzi S
Cattedra di Chirurgia Apparato Digerente, Università di Pavia-I.R.C.C.S. Policlinico San Matteo.
Ann Ital Chir. 1994 Jan-Feb;65(1):89-97; discussion 97-8.
Massive hemorrhage from diverticular disease of the colon is a very difficult problem in abdominal emergency surgery. The pathogenesis of bleeding colonic diverticulosis is strictly correlated to the angioarchitecture of the colonic diverticular wall. Here the vasa recta penetrate the colonic wall from the serosa to the submucosa through connective tissue septa. Injurious factors arising from the colonic or diverticular lumen can produce an eccentric damage to the luminal side with intimal thickening, segmental weakening of the artery and its rupture with massive bleeding. Conventional barium enema is not able to show the source of the hemorrhage in the majority of the bleeding patients; colonoscopy, as primary emergency procedure, has significant positive findings in 41.5%-83.7% of patients. Radionuclide bleeding scans have a sensitivity rate of 86%-94%. Emergency arteriography localizes the bleeding source in higher rates ranging from 58% to 86% and is successful after intraarterial infusion of vasopressin or embolization in 47%-92% of patients. Surgical treatment for continued bleeding from diverticular disease is controversy. Segmental resection should be performed on patients with localized bleeding sources (positive arteriogram). Laparotomy, anterograde irrigation and intraoperative colonoscopy are indicated in patients with multiple bleeding sites and negative arteriography. Because the right colon is the most common site of bleeding in same cases is necessary to perform a subtotal colectomy with ileorectal anastomosis. Blind resections particularly in the elderly patients present high rebleeding rate (> 60%) and high mortality (30%) with sepsis accounting for the majority of deaths.
结肠憩室病引起的大出血是腹部急诊手术中一个非常棘手的问题。结肠憩室病出血的发病机制与结肠憩室壁的血管结构密切相关。此处,直小血管通过结缔组织间隔从浆膜层穿透结肠壁至黏膜下层。源于结肠或憩室腔的损伤因素可对腔侧产生偏心性损伤,导致内膜增厚、动脉节段性减弱及其破裂并引发大出血。传统钡剂灌肠在大多数出血患者中无法显示出血来源;结肠镜检查作为主要的急诊检查方法,在41.5% - 83.7%的患者中有显著阳性发现。放射性核素出血扫描的敏感度为86% - 94%。急诊动脉造影定位出血源的成功率较高,为58%至86%,并且在47% - 92%的患者中,经动脉内注入血管加压素或栓塞后成功止血。对于憩室病持续出血的手术治疗存在争议。对于出血源定位明确(动脉造影阳性)的患者应行节段性切除。对于有多个出血部位且动脉造影阴性的患者,应行剖腹探查、顺行灌洗及术中结肠镜检查。因为在某些病例中,右半结肠是最常见的出血部位,所以行回肠直肠吻合的次全结肠切除术是必要的。盲目切除,尤其是在老年患者中,再出血率高(> 60%)且死亡率高(30%),脓毒症是主要死因。