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A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats.

作者信息

Golub L M, Evans R T, McNamara T F, Lee H M, Ramamurthy N S

机构信息

Department of Oral Biology & Pathology, School of Dental Medicine, State University of New York at Stony Brook 11794-8702.

出版信息

Ann N Y Acad Sci. 1994 Sep 6;732:96-111. doi: 10.1111/j.1749-6632.1994.tb24728.x.

DOI:10.1111/j.1749-6632.1994.tb24728.x
PMID:7978855
Abstract
摘要

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A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats.一种化学修饰的非抗菌四环素（CMT-8）可抑制去卵巢大鼠的牙龈基质金属蛋白酶、牙周组织破坏和口外骨质流失。
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