Park Chan-Su, Kim Sang-Hyun, Lee Chong-Kil
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Pharmaceutics, College of Pharmacy, Chungbuk National University, Cheongju 28644, Korea.
Immune Netw. 2020 Dec 21;20(6):e47. doi: 10.4110/in.2020.20.e47. eCollection 2020 Dec.
Tetracyclines, which have long been used as broad-spectrum antibiotics, also exhibit a variety of nonantibiotic activities including anti-inflammatory and immunomodulatory properties. Tetracyclines bind to the 30S ribosome of the bacteria and inhibit protein synthesis. Unlike antimicrobial activity, the primary molecular target for the nonantibiotic activity of tetracycline remains to be clarified. Nonetheless, the therapeutic efficacies of tetracyclines, particularly minocycline and doxycycline, have been demonstrated in various animal models of autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis, and asthma. In this study, we summarized the anti-inflammatory and immunomodulatory activities of tetracyclines, focusing on the mechanisms underlying these activities. In addition, we highlighted the on-going or completed clinical trials with reported outcomes.
四环素长期以来一直被用作广谱抗生素，还具有多种非抗生素活性，包括抗炎和免疫调节特性。四环素与细菌的30S核糖体结合并抑制蛋白质合成。与抗菌活性不同，四环素非抗生素活性的主要分子靶点仍有待阐明。尽管如此，四环素，特别是米诺环素和多西环素，已在各种自身免疫性疾病的动物模型中，如多发性硬化症、类风湿性关节炎和哮喘，显示出治疗效果。在本研究中，我们总结了四环素的抗炎和免疫调节活性，重点关注这些活性背后的机制。此外，我们还强调了已报道结果的正在进行或已完成的临床试验。
