Landmann C
Department of Radiation-Oncology, University Hospital Petersgraben, Basel, Suisse.
Ann Urol (Paris). 1994;28(4):207-20.
External beam radiation therapy is an effective, well tolerated treatment modality for localized prostate cancer with a low rate of severe morbidity. In this retrospective analysis experience with 431 patients who have been treated with definitive radiation therapy with aim at cure is presented. Median follow-up time was 4 years (range 1-17 years). Treatment was administered with 45 mega Volt photons in all cases. Does between 60-70 Gray to the prostate and 45-50 Gray to the pelvic lymph nodes have been applied. Disease-free survival rates approaching 80% in 5 years and 53% in 10 years have been achieved for disease confined to the prostate as compared to 50% at 5 years and 27% at 10 years for extracapsular disease. The prognostic significance of various factors such as stage, grade, lymph node status, method of diagnosis, and pretreatment prostate-specific antigen value has been documented and analysed. Comparison of results with those of radical prostatectomy is discussed.
外照射放疗是一种治疗局限性前列腺癌的有效且耐受性良好的治疗方式，严重并发症发生率较低。本文呈现了对431例接受根治性放疗以治愈为目的患者的回顾性分析经验。中位随访时间为4年（范围1至17年）。所有病例均采用45兆伏光子进行治疗。已对前列腺给予60至70格雷的剂量，对盆腔淋巴结给予45至50格雷的剂量。局限于前列腺的疾病5年无病生存率接近80%，10年为53%，而包膜外疾病5年为50%，10年为27%。已记录并分析了诸如分期、分级、淋巴结状态、诊断方法和治疗前前列腺特异性抗原值等各种因素的预后意义。还讨论了与根治性前列腺切除术结果的比较。
