大环内酯类抗生素可预防大鼠气管中内毒素诱导的血管渗漏和中性粒细胞聚集。
Macrolide antibiotics protect against endotoxin-induced vascular leakage and neutrophil accumulation in rat trachea.
作者信息
Tamaoki J, Sakai N, Tagaya E, Konno K
机构信息
First Department of Medicine, Tokyo Women's Medical College, Japan.
出版信息
Antimicrob Agents Chemother. 1994 Jul;38(7):1641-3. doi: 10.1128/AAC.38.7.1641.
Abstract
We studied the effects of macrolides on lipopolysaccharide (LPS)-induced airway inflammation in the rat tracheal mucosa. Erythromycin and roxithromycin dose dependently inhibited microvascular leakage and neutrophil recruitment induced by LPS. This inhibitory action on vascular permeability was abolished by neutrophil depletion.
摘要
我们研究了大环内酯类药物对大鼠气管黏膜中脂多糖（LPS）诱导的气道炎症的影响。红霉素和罗红霉素可剂量依赖性地抑制LPS诱导的微血管渗漏和中性粒细胞募集。中性粒细胞耗竭可消除这种对血管通透性的抑制作用。
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