罗红霉素和红霉素对豚鼠气管中白细胞介素8诱导的中性粒细胞募集及杯状细胞分泌的影响。
Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas.
作者信息
Tamaoki J, Nakata J, Tagaya E, Konno K
机构信息
First Department of Medicine, Tokyo Women's Medical College, Japan.
出版信息
Antimicrob Agents Chemother. 1996 Jul;40(7):1726-8. doi: 10.1128/AAC.40.7.1726.
Abstract
Inhaled interleukin 8 caused an increase in goblet cell secretion in guinea pig tracheas, which was accompanied by mucosal infiltration of neutrophils. These responses were inhibited by pretreatment with roxithromycin or erythromycin in a dose-dependent fashion. Macrolides may thus be a value in protecting against neutrophil-associated airway hypersecretion.
摘要
吸入白细胞介素8可导致豚鼠气管杯状细胞分泌增加，并伴有中性粒细胞的黏膜浸润。这些反应可被罗红霉素或红霉素预处理以剂量依赖的方式抑制。因此，大环内酯类药物可能在预防中性粒细胞相关的气道高分泌方面具有价值。
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本文引用的文献
1
Effect of clarithromycin on sputum production and its rheological properties in chronic respiratory tract infections.
Antimicrob Agents Chemother. 1995 Aug;39(8):1688-90. doi: 10.1128/AAC.39.8.1688.
2
Macrolides and immunity: effects of erythromycin and spiramycin on human mononuclear cell proliferation.
J Antimicrob Chemother. 1986 Feb;17(2):195-203. doi: 10.1093/jac/17.2.195.
3
Erythromycin-induced suppression of pulmonary antibacterial defenses. A potential mechanism of superinfection in the lung.
Am Rev Respir Dis. 1987 Nov;136(5):1207-12. doi: 10.1164/ajrccm/136.5.1207.
4
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.
J Clin Invest. 1989 Oct;84(4):1045-9. doi: 10.1172/JCI114265.
5
Erythromycin inhibits respiratory glycoconjugate secretion from human airways in vitro.
Am Rev Respir Dis. 1990 Jan;141(1):72-8. doi: 10.1164/ajrccm/141.1.72.
6
Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.
J Clin Invest. 1990 Mar;85(3):682-9. doi: 10.1172/JCI114492.
7
Neural control of goblet cell secretion in guinea pig airways.
Am J Physiol. 1990 Aug;259(2 Pt 1):L108-15. doi: 10.1152/ajplung.1990.259.2.L108.
8
Erythromycin inhibits Cl secretion across canine tracheal epithelial cells.
Eur Respir J. 1992 Feb;5(2):234-8.
9
Goblet cells in the peripheral airways in chronic bronchitis.
Am Rev Respir Dis. 1975 Jul;112(1):65-9. doi: 10.1164/arrd.1975.112.1.65.
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