卢旺达出现杜克雷嗜血杆菌对甲氧苄啶-磺胺甲恶唑耐药的情况。
Emergence of Haemophilus ducreyi resistance to trimethoprim-sulfamethoxazole in Rwanda.
作者信息
Van Dyck E, Bogaerts J, Smet H, Tello W M, Mukantabana V, Piot P
机构信息
Division of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium.
出版信息
Antimicrob Agents Chemother. 1994 Jul;38(7):1647-8. doi: 10.1128/AAC.38.7.1647.
The in vitro susceptibilities of 112 clinical isolates of Haemophilus ducreyi to six antimicrobial agents were determined. These isolates were obtained in Kigali, Rwanda, during three studies on genital ulcer disease performed in 1986 (18 isolates), 1988 (23 isolates), and 1991 (71 isolates). All H. ducreyi isolates were susceptible to azithromycin, ceftriaxone, ciprofloxacin, and erythromycin; all isolates obtained in 1986 were also susceptible to trimethoprim and to the combination trimethoprim-sulfamethoxazole. In contrast, 39 and 9% of the isolates obtained in 1988 and 59 and 48% of the isolates obtained in 1991 were resistant to trimethoprim (MIC, > or = 4.0 mg/liter) and trimethoprim-sulfamethoxazole (MIC, < or = 4.0/76 mg/liter), respectively. These data indicate that trimethoprim-sulfamethoxazole can no longer be recommended for use in the treatment of chancroid in Rwanda, and possibly elsewhere in Africa.
测定了112株杜克雷嗜血杆菌临床分离株对六种抗菌药物的体外敏感性。这些分离株是在卢旺达基加利进行的三项关于生殖器溃疡疾病的研究中获得的，分别来自1986年（18株）、1988年（23株）和1991年（71株）。所有杜克雷嗜血杆菌分离株对阿奇霉素、头孢曲松、环丙沙星和红霉素敏感；1986年获得的所有分离株对甲氧苄啶以及甲氧苄啶-磺胺甲恶唑合剂也敏感。相比之下，1988年获得的分离株中分别有39%和9%、1991年获得的分离株中分别有59%和48%对甲氧苄啶（MIC，≥4.0毫克/升）和甲氧苄啶-磺胺甲恶唑（MIC，≤4.0/76毫克/升）耐药。这些数据表明，在卢旺达以及非洲其他可能的地方，不再推荐使用甲氧苄啶-磺胺甲恶唑治疗软下疳。
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