来自泰国和美国的杜克嗜血杆菌分离株对目前推荐的以及新型软下疳治疗药物的体外敏感性。
In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and the United States to currently recommended and newer agents for treatment of chancroid.
作者信息
Knapp J S, Back A F, Babst A F, Taylor D, Rice R J
机构信息
Division of Sexually Transmitted Diseases Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
出版信息
Antimicrob Agents Chemother. 1993 Jul;37(7):1552-5. doi: 10.1128/AAC.37.7.1552.
We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isolates were susceptible to < or = 0.25 microgram of ceftriaxone per ml, < or less 0.5 microgram of cefixime per ml, < or = 0.125 microgram of ciprofloxacin per ml, and < or = 0.06 microgram of ofloxacin per ml. Erythromycin was active against all isolates (MIC for 90% of isolates tested, 0.25 microgram/ml), as was azithromycin (MIC, < or = micrograms/ml). In contrast, all but one isolate were resistant to > or = 8.0 micrograms of tetracycline per ml, 11.1% of the isolates were resistant to and 40.9% of the isolates were resistant to trimethoprim-sulfamethoxazole (MIC, > or = 4/76 microgram/ml.)
我们测定了来自泰国（29株）和旧金山（25株）的54株杜克雷嗜血杆菌对青霉素G、四环素、阿莫西林-克拉维酸、头孢曲松、头孢克肟、红霉素、阿奇霉素、环丙沙星、氧氟沙星和甲氧苄啶-磺胺甲恶唑的体外敏感性。分离株对每毫升头孢曲松≤0.25微克、每毫升头孢克肟≤0.5微克、每毫升环丙沙星≤0.125微克和每毫升氧氟沙星≤0.06微克敏感。红霉素对所有分离株均有活性（90%受试分离株的MIC为0.25微克/毫升），阿奇霉素也是如此（MIC≤微克/毫升）。相比之下，除一株分离株外，所有分离株对每毫升≥8.0微克的四环素耐药，11.1%的分离株对甲氧苄啶-磺胺甲恶唑耐药，40.9%的分离株对甲氧苄啶-磺胺甲恶唑耐药（MIC≥4/76微克/毫升）。
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