Yamazaki M
Dept. of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University.
Gan To Kagaku Ryoho. 1994 Nov;21(15):2679-87.
TNF-alpha, a cytokine with tumor necrosis activity produced by many types of cells including macrophages, was recently recognized as an important host defense factor that affects not only malignant cells, but many kinds of normal cells. Clinical applications of TNF-alpha are now limited, but local injection or local production of TNF-alpha should be given closer consideration in antitumor trials. Here we described the TNF receptor family and TNF-alpha-driven inflammation, and also discussed the physiological roles of TNF-alpha.
肿瘤坏死因子-α（TNF-α）是一种由包括巨噬细胞在内的多种细胞产生的具有肿瘤坏死活性的细胞因子，最近被认为是一种重要的宿主防御因子，它不仅影响恶性细胞，还影响多种正常细胞。目前TNF-α的临床应用有限，但在抗肿瘤试验中应更密切地考虑局部注射或局部产生TNF-α。在此，我们描述了TNF受体家族和TNF-α驱动的炎症反应，并讨论了TNF-α的生理作用。
