Warren J S, Ward P A, Johnson K J
Department of Pathology, University of Michigan Medical School, Ann Arbor.
Mod Pathol. 1988 May;1(3):242-7.
In recent years intense research activity has been directed toward characterizing polypeptide mediators that regulate growth, differentiation, and function of cells involved in inflammation, immunity, and hematopoiesis. Tumor necrosis factor (TNF), or cachectin, is one of these cytokines. This review will summarize important observations that have led to our current definition of TNF. The relationship of TNF to other cytokines and basic TNF biology are discussed. Particular attention is directed toward the evidence which implicates TNF as an important mediator of acute inflammation.
近年来，大量的研究活动致力于表征调节参与炎症、免疫和造血过程的细胞生长、分化和功能的多肽介质。肿瘤坏死因子（TNF），即恶病质素，就是这些细胞因子之一。本综述将总结那些促成我们目前对TNF定义的重要观察结果。还将讨论TNF与其他细胞因子的关系以及TNF的基础生物学特性。尤其要关注那些表明TNF是急性炎症重要介质的证据。
