Thoresen M, Haaland K, Steen P A
Department of Paediatrics, Ullevål University Hospital, Norway.
Arch Dis Child Fetal Neonatal Ed. 1994 Sep;71(2):F103-6. doi: 10.1136/fn.71.2.f103.
To determine whether cerebral blood flow velocity (CBFV) measurements were representative of cerebral blood flow (CBF) changes in pathological flow situations five newborn piglets were investigated. They underwent measurements of CBF by electromagnetic flowmetry on a modified common carotid artery where extracerbral branches were tied off simultaneously with Doppler recording either from the same precerebral or an intracerebral artery. The two methods agreed well within moderate carbon dioxide and blood pressure changes. During severe hypotension and hypertension Doppler overestimated CBF by 25-100%. During transfusion of infected or incompatible blood the two methods differed in opposite directions with Doppler reading from 30-200% of CBF. Transfusion of chilled blood caused CBFV to overestimate 15% and heated blood caused 20% underestimation. These results could be explained by diameter changes in response to variation in myogenic tone or vasoactive substances. CBFV measurements could be seriously misleading in severe clinical derangements where neonatal brain damage might occur.
为了确定脑血流速度（CBFV）测量值是否能代表病理血流情况下的脑血流量（CBF）变化，对5只新生仔猪进行了研究。通过电磁流量计在改良的颈总动脉上测量CBF，同时结扎脑外分支，并使用来自同一条脑前动脉或脑内动脉的多普勒记录。在中度二氧化碳和血压变化范围内，两种方法的结果吻合良好。在严重低血压和高血压期间，多普勒测量的CBF高估了25%-100%。在输注感染或不相容血液时，两种方法的结果呈相反方向变化，多普勒读数为CBF的30%-200%。输注冷血液导致CBFV高估15%，输注热血液导致低估20%。这些结果可以通过肌源性张力或血管活性物质变化引起的直径变化来解释。在可能发生新生儿脑损伤的严重临床紊乱中，CBFV测量可能会产生严重误导。
