Takahashi Y, Harada K, Ishida A, Tamura M, Takada G
Department of Paediatrics, Akita University School of Medicine, Japan.
Arch Dis Child Fetal Neonatal Ed. 1994 Sep;71(2):F118-21. doi: 10.1136/fn.71.2.f118.
The left ventricular Frank-Starling response was studied in 15 preterm infants, less than 1500 g birth weight, and in 16 fullterm infants with patent ductus arteriosus. Left ventricular end diastolic volume (LVEDV), stroke volume, and cardiac output were calculated from biplane echocardiographic images with a modified Simpson's rule, and the left ventricular function curve was obtained by standardising with birth weight and body length. In the relationship between LVEDV and stroke volume, the slope of the regression line was significantly milder in preterm than in fullterm infants; however, there was no significant difference in the relationship between LVEDV and cardiac output. The heart rate was significantly higher in preterm than in fullterm infants. Our data indicated that the premature infants had less left ventricular reserve capacity to respond to the increased preload through the left-to-right ductal shunting than the mature ones, and that the high pulse rate made it possible to generate adequate cardiac output in premature infants.
对15名出生体重小于1500克的早产儿和16名患有动脉导管未闭的足月儿的左心室Frank-Starling反应进行了研究。采用改良的Simpson法则从双平面超声心动图图像计算左心室舒张末期容积（LVEDV）、每搏输出量和心输出量，并通过出生体重和身长标准化获得左心室功能曲线。在LVEDV与每搏输出量的关系中，早产儿回归线的斜率明显比足月儿平缓；然而，LVEDV与心输出量的关系无显著差异。早产儿的心率明显高于足月儿。我们的数据表明，与成熟儿相比，早产儿通过左向右导管分流对增加的前负荷作出反应的左心室储备能力较小，且高脉搏率使早产儿能够产生足够的心输出量。
