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An in vitro study of diamorphine permeation through premature human neonatal skin.二醋吗啡透过早产新生儿皮肤的体外研究。
Pharm Res. 1993 Apr;10(4):583-7. doi: 10.1023/a:1018958305002.
2
A lidocaine-prilocaine cream for superficial skin surgery and painful lesions.一种用于浅表皮肤手术和疼痛性病变的利多卡因-丙胺卡因乳膏。
Acta Derm Venereol. 1980;60(6):544-6. doi: 10.2340/0001555560544546.
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Development of the epidermis in the newborn.新生儿表皮的发育
Biol Neonate. 1986;49(2):74-80. doi: 10.1159/000242513.
4
Plasma concentrations of prilocaine and lidocaine and methaemoglobin formation in infants after epicutaneous application of a 5% lidocaine-prilocaine (EMLA).5%利多卡因-丙胺卡因（复方利多卡因乳膏）经皮应用于婴儿后丙胺卡因、利多卡因的血浆浓度及高铁血红蛋白的形成
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Skin permeability in the newborn.
J Invest Dermatol. 1987 Apr;88(4):409-11. doi: 10.1111/1523-1747.ep12469738.
6
The effect of iontophoresis and vehicle pH on the in-vitro permeation of lignocaine through human stratum corneum.
J Pharm Pharmacol. 1985 Oct;37(10):732-5. doi: 10.1111/j.2042-7158.1985.tb04954.x.
7
Clinical pharmacokinetics of local anaesthetics.局部麻醉药的临床药代动力学
Clin Pharmacokinet. 1979 Jul-Aug;4(4):241-78. doi: 10.2165/00003088-197904040-00001.

新生儿经皮利多卡因吸收情况

Percutaneous lignocaine absorption in newborn infants.

作者信息

Barrett D A, Rutter N

机构信息

Department of Pharmaceutical Sciences, Nottingham University.

出版信息

Arch Dis Child Fetal Neonatal Ed. 1994 Sep;71(2):F122-4. doi: 10.1136/fn.71.2.f122.

DOI:10.1136/fn.71.2.f122
PMID:7979466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1061097/
Abstract

The permeability of the skin of newborn infants to lignocaine was examined in vitro using excised skin. Samples were studied from 24 infants of gestational age 25 to 40 weeks and postnatal age 0 to 7 days. Mature skin was relatively impermeable to lignocaine, but the more premature infants showed a marked increase in absorption. There was a strong inverse correlation between gestational age and skin permeability. These findings suggest that topical lignocaine would be an effective local anaesthetic in preterm infants. Calculations indicate that there is negligible risk of toxicity due to systemic absorption.

摘要

采用离体皮肤在体外研究了新生儿皮肤对利多卡因的通透性。对24例胎龄25至40周、出生后0至7天的婴儿的皮肤样本进行了研究。成熟皮肤对利多卡因的通透性相对较低，但越是早产儿，吸收明显增加。胎龄与皮肤通透性之间存在很强的负相关。这些发现表明，局部应用利多卡因对早产儿将是一种有效的局部麻醉剂。计算表明，由于全身吸收导致中毒的风险可忽略不计。