脑瘫中的骨质减少
Osteopenia in cerebral palsy.
作者信息
Shaw N J, White C P, Fraser W D, Rosenbloom L
机构信息
Institute of Child Health, Alder Hey Children's Hospital, Liverpool.
出版信息
Arch Dis Child. 1994 Sep;71(3):235-8. doi: 10.1136/adc.71.3.235.
Abstract
The bone mineral density of the lumbar spine was assessed in nine non-ambulant children with cerebral palsy combined with measurements of serum 25-hydroxyvitamin D, parathyroid hormone, and urinary calcium excretion. Three children with recurrent fractures received treatment with bisphosphonates for periods ranging from 12-18 months. All the children demonstrated a severe reduction in bone mineral density even when allowance was made for their body weight. There were no consistent abnormalities of vitamin D or parathyroid hormone status. Three children had gross hypercalciuria. Each of the children treated with bisphosphonates demonstrated an increment in bone density ranging from 20-40% with no apparent adverse effects.
摘要
对9名非行走型脑瘫患儿的腰椎骨密度进行了评估，并测定了血清25-羟维生素D、甲状旁腺激素和尿钙排泄量。3名反复骨折的患儿接受了双膦酸盐治疗，疗程为12至18个月。即使考虑到他们的体重，所有患儿的骨密度仍严重降低。维生素D或甲状旁腺激素状态没有一致的异常。3名患儿有严重的高钙尿症。接受双膦酸盐治疗的每名患儿骨密度均增加了20%至40%，且无明显不良反应。
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