癫痫患者长期抗惊厥治疗导致的骨软化症。
Osteomalacia with long-term anticonvulsant therapy in epilepsy.
作者信息
Dent C E, Richens A, Rowe D J, Stamp T C
出版信息
Br Med J. 1970 Oct 10;4(5727):69-72. doi: 10.1136/bmj.4.5727.69.
Abstract
The investigation and treatment of osteomalacia are described in four patients with epilepsy treated with long-term anticonvulsant therapy. It is suggested that drug-mediated enzyme induction may be the mechanism responsible by causing a greatly increased inactivation of vitamin D in these patients.
摘要
本文描述了4例长期接受抗惊厥治疗的癫痫患者骨软化症的调查与治疗情况。研究表明，药物介导的酶诱导作用可能是导致这些患者维生素D失活大幅增加的原因。
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