在发生一例致命病例后，一家儿童保育中心出现侵袭性A群链球菌携带情况。
Invasive group A streptococcus carriage in a child care centre after a fatal case.
作者信息
Engelgau M M, Woernle C H, Schwartz B, Vance N J, Horan J M
机构信息
Epidemic Intelligence Service, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Atlanta, Georgia.
出版信息
Arch Dis Child. 1994 Oct;71(4):318-22. doi: 10.1136/adc.71.4.318.
After a fatal case of invasive group A streptococcal disease, serotype T-1, in a child care centre, group A streptococcal T-1 prevalence was measured and risk factors for carriage were determined. A total of 87% (224/258) had throat culture tests. Group A streptococcus was isolated from 57 (25%), and of the 50 isolates serotyped, 38 (76%) were T-1. Group A streptococcal T-1 prevalence was 18% (38/217) and six of nine rooms had children with group A streptococcal T-1 isolates. The risk of group A streptococcal T-1 carriage was increased for children who shared the index case's room (odds ratio (OR) = 2.7; 95% confidence interval (CI) = 0.8 to 9.4) and for each additional hour per week in child care (OR = 1.03; 95% CI = 1.001 to 1.061); and decreased in children taking antibiotics in the preceding four weeks (OR = 0.2; 95% CI = 0.1 to 0.9). Carriage of the invasive group A streptococcal strain could not be determined by identified risk factors alone.
在一家日托中心出现一例由A群链球菌T-1型引起的侵袭性疾病致死病例后，对A群链球菌T-1型的流行情况进行了测量，并确定了携带该菌的危险因素。共有87%（224/258）的人接受了咽喉培养检测。从57人（25%）中分离出A群链球菌，在50株进行血清分型的菌株中，38株（76%）为T-1型。A群链球菌T-1型的流行率为18%（38/217），九个房间中有六个房间有携带A群链球菌T-1型菌株的儿童。与首例病例同住一室的儿童携带A群链球菌T-1型的风险增加（比值比（OR）=2.7；95%置信区间（CI）=0.8至9.4），每周在日托中心多待一小时，风险也增加（OR = 1.03；95% CI = 1.001至1.061）；而在过去四周内服用过抗生素的儿童，携带风险降低（OR = 0.2；95% CI = 0.1至0.9）。仅通过已确定的危险因素无法确定侵袭性A群链球菌菌株的携带情况。
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