Klein M, Rosen A, Graf A, Lahousen M, Kucera H, Pakisch B, Vavra N, Beck A
Department of Gynecology, Hanusch-Krankenhaus, Vienna, Austria.
Arch Gynecol Obstet. 1994;255(3):141-6. doi: 10.1007/BF02390941.
To evaluate retrospectively the importance of invasion beyond the basement membrane on overall survival in Fallopian tube carcinoma and its influence on the necessity of postoperative adjuvant therapy (stage 0 vs. stage I).
In a nationwide analysis the data of 51 patients were evaluated. The participating departments provided the study center with histologic specimens. A re-staging was done according to the FIGO-classification for Fallopian tube carcinomas. Stage 0 patients received no further postoperative therapy, in stage I patients were divided in 2 groups to evaluate the impact of postoperative adjuvant therapy (chemotherapy vs. irradiation).
Patients of stage 0 had a significantly better prognosis than patients of stage I (p = 0.035). Stage I patients treated by irradiation showed a significantly better prognosis than patients treated by chemotherapy (p = 0.017).
Tumour penetration through the basement membrane causes prognosis to deteriorate significantly (5-year survival rate about 50% in stage I). Postoperative therapy is thus indicated with stage I disease. Irradiation seems to give better results than chemotherapy.
回顾性评估输卵管癌中基底膜外浸润对总生存期的重要性及其对术后辅助治疗必要性的影响（0期与I期）。
在一项全国性分析中，对51例患者的数据进行了评估。参与的科室向研究中心提供了组织学标本。根据国际妇产科联盟（FIGO）输卵管癌分类进行了重新分期。0期患者未接受进一步的术后治疗，I期患者分为两组以评估术后辅助治疗（化疗与放疗）的影响。
0期患者的预后明显好于I期患者（p = 0.035）。接受放疗的I期患者的预后明显好于接受化疗的患者（p = 0.017）。
肿瘤穿透基底膜会导致预后显著恶化（I期的5年生存率约为50%）。因此，I期疾病需要进行术后治疗。放疗似乎比化疗效果更好。
