Alvar J, Molina R, San Andrés M, Tesouro M, Nieto J, Vitutia M, González F, San Andrés M D, Boggio J, Rodriguez F
Laboratorio de Referencia de Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain.
Ann Trop Med Parasitol. 1994 Aug;88(4):371-8. doi: 10.1080/00034983.1994.11812879.
Six naturally infected dogs [two with no signs of leishmaniasis ('asymptomatic'), two with a few signs ('oligosymptomatic') and two with many signs ('polysymptomatic')] were studied before and after chemotherapy. Another two, non-infected dogs were kept as controls. The dogs were studied clinically, haematologically and parasitologically five times over 11 months and their infectivity to sandflies was evaluated before and after the treatment. The 'asymptomatic' dogs were as infective to sandflies as the 'symptomatic' before treatment but all dogs were un-infective for at least a few months following chemotherapy. Treatment led to a temporary improvement in the clinical and biochemical condition of most of the dogs, the symptomatic dogs becoming asymptomatic, but parasitological cure was uncommon after 10 months' follow-up. There was often no correlation between clinical condition, parasitological condition and infectivity to sandflies. Some dogs from both the 'asymptomatic' and 'symptomatic' groups became infective to sandflies several months post-treatment.
对6只自然感染的犬（2只无利什曼病体征的“无症状”犬、2只有少量体征的“轻度症状”犬和2只有多种体征的“多症状”犬）在化疗前后进行了研究。另外2只未感染的犬作为对照。在11个月内对这些犬进行了5次临床、血液学和寄生虫学检查，并在治疗前后评估了它们对白蛉的感染性。“无症状”犬在治疗前对白蛉的感染性与“有症状”犬相同，但化疗后所有犬至少有几个月无感染性。治疗使大多数犬的临床和生化状况暂时改善，有症状的犬变为无症状，但随访10个月后寄生虫学治愈并不常见。临床状况、寄生虫学状况与对白蛉的感染性之间通常没有相关性。“无症状”组和“有症状”组的一些犬在治疗后几个月对白蛉具有感染性。
