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犬利什曼病的严格评价主题：治疗一个月后，使用锑剂和别嘌呤醇治疗与使用米替福新和别嘌呤醇治疗在临床和临床病理疗效上是否相同？

Critically Appraised Topic on Canine Leishmaniosis: Does Treatment with Antimonials and Allopurinol Have the Same Clinical and Clinicopathological Efficacy as Treatment with Miltefosine and Allopurinol, after One Month of Treatment?

作者信息

García Marina, Ferrer Lluís, Ordeix Laura

机构信息

Departament de Medicina i Cirurgia Animals, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

出版信息

Vet Sci. 2024 May 22;11(6):231. doi: 10.3390/vetsci11060231.

DOI:10.3390/vetsci11060231
PMID:38921978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11209642/
Abstract

The treatment of canine leishmaniosis commonly involves meglumine antimoniate with allopurinol or miltefosine with allopurinol. This study aims to compare the clinical and clinicopathological efficacy at 28-30 days of conventional dosing regimens for both treatments using the critically appraised topic methodology. A comprehensive search across three databases (PubMed, CAB Abstracts, and Web of Science) from March 2004 to September 2023 yielded 16 relevant articles, encompassing 325 ogs treated with meglumine antimoniate and allopurinol, and 273 dogs treated with miltefosine and allopurinol. The findings indicated a significantly higher rate of complete clinical cure in the group treated with meglumine antimoniate and allopurinol. Most dogs in both groups exhibited improvement in clinicopathological alterations after one month of treatment. No significant difference was observed in the number of dogs that showed a negative qPCR between the two groups, one month post-treatment. However, quantitative serology results were not commonly reported in the available data and therefore this aspect could not be compared.

摘要

犬利什曼病的治疗通常包括使用葡甲胺锑酸盐联合别嘌呤醇或米替福新联合别嘌呤醇。本研究旨在采用严格评价主题方法，比较两种治疗方法常规给药方案在28 - 30天时的临床和临床病理疗效。对2004年3月至2023年9月期间三个数据库（PubMed、CAB文摘和科学网）进行的全面检索产生了16篇相关文章，其中包括325只接受葡甲胺锑酸盐和别嘌呤醇治疗的犬，以及273只接受米替福新和别嘌呤醇治疗的犬。研究结果表明，接受葡甲胺锑酸盐和别嘌呤醇治疗的组完全临床治愈的比例显著更高。两组中的大多数犬在治疗一个月后临床病理改变均有改善。治疗一个月后，两组中qPCR结果为阴性的犬只数量没有显著差异。然而，现有数据中通常未报告定量血清学结果，因此无法对这方面进行比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d306/11209642/454401a043d6/vetsci-11-00231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d306/11209642/454401a043d6/vetsci-11-00231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d306/11209642/454401a043d6/vetsci-11-00231-g001.jpg

相似文献

[1]
Critically Appraised Topic on Canine Leishmaniosis: Does Treatment with Antimonials and Allopurinol Have the Same Clinical and Clinicopathological Efficacy as Treatment with Miltefosine and Allopurinol, after One Month of Treatment?

Vet Sci. 2024-5-22

[2]
Long-term follow-up of dogs with leishmaniosis treated with meglumine antimoniate plus allopurinol versus miltefosine plus allopurinol.

Parasit Vectors. 2015-5-28

[3]
A randomized, blinded, controlled clinical trial comparing the efficacy of aminosidine (paromomycin)-allopurinol combination with the efficacy of meglumine antimoniate-allopurinol combination for the treatment of canine leishmaniosis due to Leishmania infantum.

Exp Parasitol. 2020-4-28

[4]
Meglumine Antimoniate and Miltefosine Combined With Allopurinol Sustain Pro-inflammatory Immune Environments During Canine Leishmaniosis Treatment.

Front Vet Sci. 2019-10-18

[5]
Retrospective Long-Term Evaluation of Miltefosine-Allopurinol Treatment in Canine Leishmaniosis.

Pathogens. 2023-6-22

[6]
Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis.

Vet Dermatol. 2009-10

[7]
Survival time and prognostic factors in canine leishmaniosis in a non-endemic country treated with a two-phase protocol including initial allopurinol monotherapy.

Parasit Vectors. 2023-5-15

[8]
Infectivity to Phlebotomus perniciosus of dogs naturally parasitized with Leishmania infantum after different treatments.

Parasit Vectors. 2011-4-13

[9]
Evaluation of nephrotoxicity and ototoxicity of aminosidine (paromomycin)-allopurinol combination in dogs with leishmaniosis due to Leishmania infantum: A randomized, blinded, controlled study.

Exp Parasitol. 2019-9-17

[10]
Diagnosis and clinical management of canine leishmaniosis by general veterinary practitioners: a questionnaire-based survey in Portugal.

Parasit Vectors. 2021-6-7

本文引用的文献

[1]
Retrospective Long-Term Evaluation of Miltefosine-Allopurinol Treatment in Canine Leishmaniosis.

Pathogens. 2023-6-22

[2]
Leishmaniasis.

Vet Clin North Am Small Anim Pract. 2022-11

[3]
Canine Leishmaniasis: Update on Epidemiology, Diagnosis, Treatment, and Prevention.

Vet Sci. 2022-7-27

[4]
Clinical and parasitological impact of short-term treatment using miltefosine and allopurinol monotherapy or combination therapy in canine visceral leishmaniasis.

Rev Bras Parasitol Vet. 2022

[5]
Comparative study of the use of miltefosine, miltefosine plus allopurinol, and allopurinol in dogs with visceral leishmaniasis.

Exp Parasitol. 2020-7-3

[6]
Meglumine Antimoniate and Miltefosine Combined With Allopurinol Sustain Pro-inflammatory Immune Environments During Canine Leishmaniosis Treatment.

Front Vet Sci. 2019-10-18

[7]
Nostril mass caused by Leishmania spp. in a dog.

Vet Ital. 2018-9-30

[8]
Clinicopathological findings in sick dogs naturally infected with Leishmania infantum: Comparison of five different clinical classification systems.

Res Vet Sci. 2017-11-10

[9]
Diagnostic Challenges in the Era of Canine Leishmania infantum Vaccines.

Trends Parasitol. 2017-9

[10]
Novel Areas for Prevention and Control of Canine Leishmaniosis.

Trends Parasitol. 2017-9

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