Vicent D, Villanueva-Penacarrillo M L, Malaisse-Lagae F, Leclercq-Meyer V, Valverde I, Malaisse W J
Fundacion Jimenez Diaz, Centro Asociado al Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
Arch Int Pharmacodyn Ther. 1994 Mar-Apr;327(2):246-50.
Both the monomethyl and dimethyl esters of succinic acid, administered intravenously to fasted and anesthetized rats, caused a rapid increase in plasma insulin. A positive insulin secretory response to succinic acid monomethyl ester was also observed after intraperitoneal injection to fed and conscious rats. On a molar basis, stimulation of the insulin release, evoked by succinic acid esters, represented about twice that caused by D-glucose. It is speculated that succinic acid esters may be efficient insulin secretagogues even in those models of noninsulin-dependent diabetes characterized by a site-specific defect in the transport of D-glucose or in the early steps of its catabolism in the pancreatic B-cell.
将琥珀酸的单甲酯和二甲酯静脉注射给禁食并麻醉的大鼠后，二者均会使血浆胰岛素迅速增加。给喂食且清醒的大鼠腹腔注射琥珀酸单甲酯后，也观察到了对琥珀酸单甲酯的阳性胰岛素分泌反应。以摩尔计，琥珀酸酯引起的胰岛素释放刺激约为D-葡萄糖引起的两倍。据推测，即使在那些以D-葡萄糖转运或其在胰腺β细胞中分解代谢早期步骤存在位点特异性缺陷为特征的非胰岛素依赖型糖尿病模型中，琥珀酸酯也可能是有效的胰岛素促分泌剂。
