Akkan A G, Malaisse W J
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Diabetes Res. 1993;23(2):55-63.
In adult rats injected intravenously with streptozotocin (STZ: 20 or 40 mg/kg body wt) and examined 13 days later, the secretory response of the perfused pancreas to D-glucose is impaired. A paradoxical inhibition of insulin release is even observed in the perfused pancreas of rats given the high STZ dose. When pulses of succinate monomethyl ester (SAM: 60 mg) were administered intraperitoneally three times a day for one week from the 6th to 12th day after STZ injection, no obvious difference in insulin output from the perfused pancreas stimulated with either D-glucose or SAM was observed between SAM-treated and untreated rats first injected with the low STZ dose. However, in rats first injected with the high STZ dose, the secretory response to SAM was higher in SAM-treated than untreated animals. These findings raise the view that suitable non-glucidic nutrient secretagogues might improve, in a long term manner, the secretory potential of the endocrine pancreas in animal models of diabetes characterized by a preferential impairment of the B-cell response to D-glucose.
给成年大鼠静脉注射链脲佐菌素（STZ：20或40毫克/千克体重），13天后进行检查，发现灌注胰腺对D-葡萄糖的分泌反应受损。在给予高剂量STZ的大鼠的灌注胰腺中甚至观察到胰岛素释放的反常抑制。从注射STZ后的第6天到第12天，每天腹腔注射三次琥珀酸单甲酯（SAM：60毫克），持续一周，首次注射低剂量STZ的SAM处理大鼠和未处理大鼠之间，灌注胰腺对D-葡萄糖或SAM刺激的胰岛素输出没有明显差异。然而，在首次注射高剂量STZ的大鼠中，SAM处理组对SAM的分泌反应高于未处理组动物。这些发现提出了这样一种观点，即合适的非糖类营养促分泌剂可能长期改善以B细胞对D-葡萄糖反应优先受损为特征的糖尿病动物模型中内分泌胰腺的分泌潜能。
