3α-雄烷二醇葡糖苷酸在绝经前多毛症女性中的临床应用价值。

The clinical usefulness of 3 alpha-androstanediol glucuronide in premenopausal women with hirsutism.

作者信息

Moses R G, Theile H, Colagiuri S

机构信息

Department of Endocrinology, Prince of Wales Hospital, Randwick, New South Wales.

出版信息

Aust N Z J Obstet Gynaecol. 1994 May;34(2):208-10. doi: 10.1111/j.1479-828x.1994.tb02694.x.

DOI:10.1111/j.1479-828x.1994.tb02694.x

PMID:7980317

Abstract

A biochemical parameter correlating with the clinical assessment of the severity of hirsutism and changing appropriately with the clinical response to treatment would be extremely useful. Preliminary reports of androstanediol glucuronide indicated that it was a peripherally-derived androgen and had a high correlation with clinical gradings of hirsutism. More recent reports have cast doubts on this association. This paper presents an evaluation of the clinical usefulness of androstanediol in 121 consecutive premenopausal patients with hirsutism. Androstanediol had a positive correlation with the clinical grading of hirsutism (p < 0.02) and the BMI (p < 0.01) but a negative correlation with age (p < 0.01). After adjustment for the effects of age and BMI there was no significant association between the degree of hirsutism and the level of androstanediol.

摘要

一个与多毛症严重程度的临床评估相关且随治疗的临床反应而适当变化的生化参数将非常有用。雄烷二醇葡糖苷酸的初步报告表明它是一种外周来源的雄激素，与多毛症的临床分级高度相关。最近的报告对这种关联提出了质疑。本文对121例连续的绝经前多毛症患者中雄烷二醇的临床实用性进行了评估。雄烷二醇与多毛症的临床分级呈正相关（p < 0.02），与体重指数呈正相关（p < 0.01），但与年龄呈负相关（p < 0.01）。在调整年龄和体重指数的影响后，多毛症程度与雄烷二醇水平之间无显著关联。