Fraser M J
Children's Leukaemia and Cancer Research Centre, University of New South Wales, Randwick, Sydney, Australia.
Bioessays. 1994 Oct;16(10):761-6. doi: 10.1002/bies.950161011.
Endo-exonucleases from E. coli to man, although very different proteins, are multifunctional enzymes with similar enzymatic activities. They probably have two common but opposing biological roles. On the one hand, they promote survival of the organism by acting in recombination and recombinational DNA repair to diversify and help preserve the genome intact. On the other hand, they degrade the genomic DNA when it is damaged beyond repair. This ensures elimination of heavily mutagenized cells from the population.
从大肠杆菌到人类的核酸内切酶和核酸外切酶，尽管是非常不同的蛋白质，但都是具有相似酶活性的多功能酶。它们可能有两个共同但相反的生物学作用。一方面，它们通过参与重组和重组DNA修复来促进生物体的存活，使基因组多样化并帮助保持其完整。另一方面，当基因组DNA受损无法修复时，它们会降解基因组DNA。这确保了从群体中清除严重诱变的细胞。
