Chalut C, Moncollin V, Egly J M
U184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
Bioessays. 1994 Sep;16(9):651-5. doi: 10.1002/bies.950160910.
The proteins that are implicated in the basal transcription of protein coding genes have now been identified. Although little is known about their function, recent data demonstrate the ability of these proteins, previously called class II transcription factors, to participate in other reactions: TBP, the TATA-box binding factor, is involved in class I and III transcription, while TFIIH has been shown to possess components that are involved in the DNA repair mechanism. The involvement of some if not all of the TFIIH subunits in transcription and repair may explain the heterogeneity of the various and sometimes completely unrelated symptoms observed in xeroderma pigmentosum, Cockayne Syndrome and trichothiodystrophy disorders.
现已鉴定出与蛋白质编码基因基础转录相关的蛋白质。尽管对其功能了解甚少，但最近的数据表明，这些以前被称为II类转录因子的蛋白质能够参与其他反应：TATA盒结合因子TBP参与I类和III类转录，而TFIIH已被证明具有参与DNA修复机制的成分。部分（如果不是全部）TFIIH亚基参与转录和修复，这可能解释了在色素性干皮病、科凯恩综合征和毛发硫营养不良症中观察到的各种有时完全不相关症状的异质性。
