Flajnik M F
Department of Microbiology and Immunology, University of Miami, FL 33101.
Bioessays. 1994 Sep;16(9):671-5. doi: 10.1002/bies.950160913.
Much was accomplished in the last decade in understanding how the adaptive immune system evolved to combat pathogens. Essential features of antigen presentation and T lymphocyte recognition were deciphered, setting the stage for further studies that elucidated basic elements of lymphocyte differentiation (including positive and negative selection during lymphocyte ontogeny) and the major interactions that occur among cells in secondary lymphoid organs in an ongoing immune response. The major challenges of today are found in the burgeoning fields of programmed cells death, enzymology of recombination and somatic mutation, development of memory, and the recognition of pathogens by unconventional lymphocytes.
在过去十年里，我们在理解适应性免疫系统如何进化以对抗病原体方面取得了很大进展。抗原呈递和T淋巴细胞识别的基本特征已被破解，为进一步研究奠定了基础，这些研究阐明了淋巴细胞分化的基本要素（包括淋巴细胞发育过程中的阳性和阴性选择）以及正在进行的免疫反应中次级淋巴器官内细胞间发生的主要相互作用。当今的主要挑战存在于细胞程序性死亡、重组酶学和体细胞突变、记忆形成以及非常规淋巴细胞对病原体的识别等新兴领域。
