不同实验性骨质疏松大鼠模型中骨骼的机械强度

The mechanical strength of bone in different rat models of experimental osteoporosis.

作者信息

Peng Z, Tuukkanen J, Zhang H, Jämsä T, Väänänen H K

机构信息

Department of Anatomy, University of Oulu, Finland.

出版信息

Bone. 1994 Sep-Oct;15(5):523-32. doi: 10.1016/8756-3282(94)90276-3.

DOI:10.1016/8756-3282(94)90276-3

PMID:7980963

Abstract

In order to discover good parameters for experimental osteoporosis, we measured the failure load of the femoral neck and the bending strength of the tibia in orchidectomized (ORC) (20 rats for 4 weeks), ovariectomized (OVX) (28 rats for 6 weeks), and immobilized (IMM) (33 rats for 3 weeks) rats. Each of these operations led to a significant decrease in trabecular bone volume when compared with corresponding controls (p < 0.001). The ash weight of femurs was significantly decreased in ORC (p < 0.05) and IMM (p < 0.001) rats, but not in OVX rats. Growth of the femur was somewhat slower in ORC (p < 0.05) and IMM rats (p < 0.05), but not in OVX animals. All three osteoporosis models showed significant decreases in the maximal load of the femoral neck (ORC: 23.9%, p < 0.001; OVX: 15.8%, p < 0.001; IMM: 27.7%, p < 0.001), as well as in energy absorption (ORC: 43.9%, p < 0.001; OVX: 28.3%, p < 0.001; IMM: 45.3%, p < 0.001). In tibia orchidectomy reduced maximal strength and energy absorption significantly (10%, p < 0.01; 27.8%, p < 0.01), but ovariectomy decreased only maximal load (8.7%, p < 0.01) and immobilization only energy absorption (18.0%, p < 0.01). Our results suggest that the mechanical strength of the femoral neck is a sensitive indicator of bone loss in all three osteoporosis models.

摘要

为了找到实验性骨质疏松症的良好参数，我们测量了去势（ORC）（20只大鼠，持续4周）、卵巢切除（OVX）（28只大鼠，持续6周）和制动（IMM）（33只大鼠，持续3周）大鼠的股骨颈破坏载荷和胫骨弯曲强度。与相应对照组相比，这些手术中的每一种都导致小梁骨体积显著减少（p < 0.001）。ORC组（p < 0.05）和IMM组（p < 0.001）大鼠的股骨灰重显著降低，但OVX组大鼠未出现这种情况。ORC组（p < 0.05）和IMM组大鼠（p < 0.05）的股骨生长略有减慢，但OVX组动物未出现这种情况。所有三种骨质疏松模型的股骨颈最大载荷（ORC：23.9%，p < 0.001；OVX：15.8%，p < 0.001；IMM：27.7%，p < 0.001）以及能量吸收（ORC：43.9%，p < 0.001；OVX：28.3%，p < 0.001；IMM：45.3%，p < 0.001）均显著降低。在胫骨中，去势显著降低了最大强度和能量吸收（分别为10%，p < 0.01；27.8%，p < 0.01），但卵巢切除仅降低了最大载荷（8.7%，p < 0.01），制动仅降低了能量吸收（18.0%，p < 0.01）。我们的结果表明，在所有三种骨质疏松模型中，股骨颈的力学强度是骨丢失的敏感指标。