Kishimoto T
Laboratory of Cell and Developmental Biology, Faculty of Biosciences, Tokyo Institute of Technology, Yokohama, Japan.
Int J Dev Biol. 1994 Jun;38(2):185-91.
Although a major concern in the development of multicellular organisms is cell differentiation, the construction of a multicellular system essentially depends on cell multiplication, which consists of genomic duplication and segregation. Recent progress has revealed that cyclin-dependent kinases (CDKs) are key components of a cell cycle engine that governs cell proliferation. This article focuses on how CDKs induce M-phase events characterized by nuclear membrane breakdown, chromosome condensation and mitotic spindle formation to assure genomic segregation.
尽管细胞分化是多细胞生物发育过程中的一个主要问题，但多细胞系统的构建本质上依赖于细胞增殖，细胞增殖包括基因组复制和分离。最近的研究进展表明，细胞周期蛋白依赖性激酶（CDKs）是控制细胞增殖的细胞周期引擎的关键组成部分。本文重点探讨CDKs如何诱导以核膜破裂、染色体凝聚和有丝分裂纺锤体形成为特征的M期事件，以确保基因组分离。
