Munster A M
Baltimore Regional Burn Center, Francis Scott Key Medical Center, Maryland 21224.
Eur J Pediatr Surg. 1994 Aug;4(4):231-42. doi: 10.1055/s-2008-1066111.
Following thermal injury profound alterations occur in the arachidonic acid cascade, and the cytokine cascade. There are further alterations in cell mediated immunity affecting all cells of the immune system, and the neuro endocrine axis. There are profound changes in humoral immunity as well. Experimental approaches to alterations in the above systems indicate that success can be obtained in restoring normality of any individual alteration in a suitable experimental model. However, before clinical intervention can be successful, it is likely that a combination of interventional mordalities will need to be used.
热损伤后，花生四烯酸级联反应和细胞因子级联反应会发生深刻变化。细胞介导的免疫也会进一步改变，影响免疫系统的所有细胞以及神经内分泌轴。体液免疫也有深刻变化。对上述系统变化的实验方法表明，在合适的实验模型中恢复任何个体变化的正常状态都能取得成功。然而，在临床干预取得成功之前，可能需要综合使用多种干预方式。
