Csanaky G
Department of Pathology, University Medical School of Pécs, Hungary.
Histol Histopathol. 1994 Jul;9(3):571-5.
The high endothelial venule (HEV)-content and the lymphocyte migration index (LMI) of reactive lymph nodes and lymph nodes from patients with B-cell chronic lymphocytic leukaemia (B-CLL), as well as some related B-cell malignancies (lymphocytic lymphoma -LL-, prolymphocytic leukaemia -PLL-) were determined and statistically analyzed. The HEV-content and the LMI were significantly higher in reactive lymph nodes than in the low grade B-cell lymphomas and leukaemias (p < 0.001). The number of HEVs among lymphoma/leukaemia cases was the highest in LL independently of the maturation. However, the maturation of the process seems to determine the intensity of lymphocyte migration; i.e. a significantly higher LMI was found in mature (B-CLL, PF, mature; M and LL, M) than in immature subtypes (B-CLL, PF, immature -IM-; diffuse -D- and LL, IM) subtypes (levels of significance varied from p < 0.05 to p < 0.001). Based on these findings, a more intense migration of lymphocytes from blood to peripheral lymph nodes may be supposed in LL than in B-CLL, thus explaining the nodal sites of involvement in LL and the peripheral blood in B-CLL. Within the same histological categories the morphometric features in mature subtypes may implicate an enhanced HEV-lymphocyte interaction when compared to the immature subtypes.
测定并统计分析了反应性淋巴结以及B细胞慢性淋巴细胞白血病（B-CLL）患者的淋巴结、一些相关B细胞恶性肿瘤（淋巴细胞淋巴瘤-LL-、原淋巴细胞白血病-PLL-）的高内皮微静脉（HEV）含量和淋巴细胞迁移指数（LMI）。反应性淋巴结中的HEV含量和LMI显著高于低度B细胞淋巴瘤和白血病（p<0.001）。淋巴瘤/白血病病例中HEV的数量在LL中最高，与成熟度无关。然而，该过程的成熟度似乎决定了淋巴细胞迁移的强度；即，在成熟亚型（B-CLL，PF，成熟；M和LL，M）中发现的LMI显著高于未成熟亚型（B-CLL，PF，未成熟-IM-；弥漫性-D-和LL，IM）亚型（显著性水平从p<0.05到p<0.001不等）。基于这些发现，可以推测LL中淋巴细胞从血液到外周淋巴结的迁移比B-CLL中更强烈，从而解释了LL中受累的淋巴结部位以及B-CLL中的外周血情况。在相同的组织学类别中，与未成熟亚型相比，成熟亚型的形态计量学特征可能意味着HEV与淋巴细胞的相互作用增强。
