• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

关于淋巴结和 CLL 细胞：解析 CCR7 在 CLL 发病机制中的作用及其作为治疗靶点的潜力。

Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target.

机构信息

Immunology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria- Instituto de La Princesa (IIS-IP), Madrid, Spain.

IMMED S.L., Immunological and Medicinal Products, Madrid, Spain.

出版信息

Front Immunol. 2021 Mar 24;12:662866. doi: 10.3389/fimmu.2021.662866. eCollection 2021.

DOI:10.3389/fimmu.2021.662866
PMID:33841445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8024566/
Abstract

The lymph node (LN) is an essential tissue for achieving effective immune responses but it is also critical in the pathogenesis of chronic lymphocytic leukemia (CLL). Within the multitude of signaling pathways aberrantly regulated in CLL the homeostatic axis composed by the chemokine receptor CCR7 and its ligands is the main driver for directing immune cells to home into the LN. In this literature review, we address the roles of CCR7 in the pathophysiology of CLL, and how this chemokine receptor is of critical importance to develop more rational and effective therapies for this malignancy.

摘要

淋巴结（LN）是实现有效免疫反应的重要组织，但在慢性淋巴细胞白血病（CLL）的发病机制中也至关重要。在 CLL 中异常调节的众多信号通路中，由趋化因子受体 CCR7 及其配体组成的稳态轴是指导免疫细胞归巢到 LN 的主要驱动因素。在这篇文献综述中，我们探讨了 CCR7 在 CLL 病理生理学中的作用，以及这种趋化因子受体对开发更合理、更有效的这种恶性肿瘤疗法的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f99/8024566/324752b848ea/fimmu-12-662866-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f99/8024566/c56295cf12c5/fimmu-12-662866-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f99/8024566/324752b848ea/fimmu-12-662866-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f99/8024566/c56295cf12c5/fimmu-12-662866-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f99/8024566/324752b848ea/fimmu-12-662866-g002.jpg

相似文献

1
Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target.关于淋巴结和 CLL 细胞：解析 CCR7 在 CLL 发病机制中的作用及其作为治疗靶点的潜力。
Front Immunol. 2021 Mar 24;12:662866. doi: 10.3389/fimmu.2021.662866. eCollection 2021.
2
Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia.分析稳态趋化因子 CCL19 和 CCL21 诱导 B 细胞慢性淋巴细胞白血病中迁移和生存途径。
Exp Hematol. 2010 Sep;38(9):756-64, 764.e1-4. doi: 10.1016/j.exphem.2010.05.003. Epub 2010 May 19.
3
Effect of ibrutinib on CCR7 expression and functionality in chronic lymphocytic leukemia and its implication for the activity of CAP-100, a novel therapeutic anti-CCR7 antibody.伊布替尼对慢性淋巴细胞白血病中 CCR7 表达和功能的影响及其对新型治疗性抗 CCR7 抗体 CAP-100 活性的影响。
Cancer Immunol Immunother. 2022 Mar;71(3):627-636. doi: 10.1007/s00262-021-03014-2. Epub 2021 Jul 23.
4
Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma.趋化因子受体CXCR4和CCR7的表达与B细胞慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的疾病进展
Mayo Clin Proc. 2004 Mar;79(3):318-25. doi: 10.4065/79.3.318.
5
Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL.用新型抗 CCR7 治疗性抗体靶向癌症归巢至淋巴结：CLL 的范例。
MAbs. 2021 Jan-Dec;13(1):1917484. doi: 10.1080/19420862.2021.1917484.
6
Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia.增强的趋化因子受体回收和 S1P1 表达受损促进慢性淋巴细胞白血病白血病细胞浸润淋巴结。
Cancer Res. 2015 Oct 1;75(19):4153-63. doi: 10.1158/0008-5472.CAN-15-0986. Epub 2015 Aug 17.
7
The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes.趋化因子受体CCR7和α4整合素对于慢性淋巴细胞白血病细胞迁移至淋巴结很重要。
Blood. 2002 Apr 15;99(8):2977-84. doi: 10.1182/blood.v99.8.2977.
8
Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia.非典型趋化因子受体 CRAM 在调节 B 细胞慢性淋巴细胞白血病中 CCL19 诱导的 CCR7 反应中的作用。
Mol Cancer. 2010 Nov 22;9:297. doi: 10.1186/1476-4598-9-297.
9
Survival and Immunosuppression Induced by Hepatocyte Growth Factor in Chronic Lymphocytic Leukemia.肝细胞生长因子诱导慢性淋巴细胞白血病的生存及免疫抑制作用
Curr Mol Med. 2017;17(1):24-33. doi: 10.2174/1566524017666170220095838.
10
Nurselike cells sequester B cells in disorganized lymph nodes in chronic lymphocytic leukemia via alternative production of CCL21.成纤维样细胞通过 CCL21 的替代产生将 B 细胞隔离在慢性淋巴细胞白血病中紊乱的淋巴结内。
Blood Adv. 2022 Aug 23;6(16):4691-4704. doi: 10.1182/bloodadvances.2021006169.

引用本文的文献

1
Dynamic stimulation promotes functional tissue-like organization of a 3D human lymphoid microenvironment model in vitro.动态刺激促进体外三维人淋巴微环境模型的功能性组织样结构形成。
Cell Rep Methods. 2025 Jul 21;5(7):101105. doi: 10.1016/j.crmeth.2025.101105. Epub 2025 Jul 11.
2
CX3CR1 age-associated CD4 T cells contribute to synovial inflammation in late-onset rheumatoid arthritis.CX3CR1 年龄相关的 CD4 T 细胞促成迟发性类风湿关节炎中的滑膜炎症。
Inflamm Regen. 2025 Feb 6;45(1):4. doi: 10.1186/s41232-025-00367-4.
3
Proliferating CLL cells express high levels of CXCR4 and CD5.

本文引用的文献

1
CCR7 as a novel therapeutic target in t-cell PROLYMPHOCYTIC leukemia.CCR7作为T细胞原淋巴细胞白血病的新型治疗靶点。
Biomark Res. 2020 Oct 24;8:54. doi: 10.1186/s40364-020-00234-z. eCollection 2020.
2
Directing traffic in the germinal center roundabout.引导生发中心环形路线中的细胞流动。
Nat Immunol. 2020 Jun;21(6):599-601. doi: 10.1038/s41590-020-0690-9.
3
Mogamulizumab in the treatment of advanced mycosis fungoides and Sézary syndrome: safety and efficacy.莫格利珠单抗治疗晚期蕈样霉菌病和赛泽里综合征：安全性和疗效。
增殖性慢性淋巴细胞白血病细胞表达高水平的CXCR4和CD5。
Hemasphere. 2024 Dec 17;8(12):e70064. doi: 10.1002/hem3.70064. eCollection 2024 Dec.
4
NK Cells in the Lymph Nodes and Their Role in Anti-Tumour Immunity.淋巴结中的自然杀伤细胞及其在抗肿瘤免疫中的作用。
Biomedicines. 2024 Jul 25;12(8):1667. doi: 10.3390/biomedicines12081667.
5
StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling.StellarPath：分层垂直多组学分类器结合稳定标志物和可解释的相似性网络进行患者特征分析。
PLoS Comput Biol. 2024 Apr 12;20(4):e1012022. doi: 10.1371/journal.pcbi.1012022. eCollection 2024 Apr.
6
Construction of ceRNA prognostic model based on the CCR7/CCL19 chemokine axis as a biomarker in breast cancer.基于 CCR7/CCL19 趋化因子轴作为乳腺癌生物标志物的 ceRNA 预后模型的构建。
BMC Med Genomics. 2023 Oct 21;16(1):254. doi: 10.1186/s12920-023-01683-9.
7
The Multi-Functional Roles of CCR7 in Human Immunology and as a Promising Therapeutic Target for Cancer Therapeutics.CCR7在人类免疫学中的多功能作用及其作为癌症治疗中有前景的治疗靶点
Front Mol Biosci. 2022 Jul 6;9:834149. doi: 10.3389/fmolb.2022.834149. eCollection 2022.
8
Ibrutinib Does Not Impact CCR7-Mediated Homeostatic Migration in T-Cells from Chronic Lymphocytic Leukemia Patients.依鲁替尼不影响慢性淋巴细胞白血病患者T细胞中CCR7介导的稳态迁移。
Cancers (Basel). 2022 May 31;14(11):2729. doi: 10.3390/cancers14112729.
9
Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake.趋化因子受体 7 向单体形式转变增强了 CCL19 的结合和摄取。
Cells. 2022 Apr 25;11(9):1444. doi: 10.3390/cells11091444.
10
C-C Chemokine Receptor 7 in Cancer.C-C 趋化因子受体 7 在癌症中的作用。
Cells. 2022 Feb 14;11(4):656. doi: 10.3390/cells11040656.
Expert Rev Anticancer Ther. 2020 Jun;20(6):447-452. doi: 10.1080/14737140.2020.1760096. Epub 2020 Apr 28.
4
Evaluation of therapeutic targeting of CCR7 in acute graft-versus-host disease.评估 CCR7 在急性移植物抗宿主病中的治疗靶点作用。
Bone Marrow Transplant. 2020 Oct;55(10):1935-1945. doi: 10.1038/s41409-020-0830-8. Epub 2020 Feb 21.
5
Monocytic myeloid-derived suppressor cells in chronic lymphocytic leukemia patients: a single center experience.慢性淋巴细胞白血病患者中的单核细胞髓系来源抑制细胞：单中心经验。
Leuk Lymphoma. 2020 Jul;61(7):1645-1652. doi: 10.1080/10428194.2020.1728747. Epub 2020 Feb 20.
6
Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing.B 细胞发育过程中 CCR7 和 CXCR4 的共表达控制 CXCR4 反应性和骨髓归巢。
Front Immunol. 2019 Dec 18;10:2970. doi: 10.3389/fimmu.2019.02970. eCollection 2019.
7
Phosphatidylinositol 3 Kinase δ Inhibitors: Present and Future.磷脂酰肌醇 3 激酶 δ 抑制剂：现状与未来。
Cancer J. 2019 Nov/Dec;25(6):394-400. doi: 10.1097/PPO.0000000000000414.
8
The life and death of the germinal center.生殖中心的生死。
Ann Diagn Pathol. 2020 Feb;44:151421. doi: 10.1016/j.anndiagpath.2019.151421. Epub 2019 Nov 13.
9
Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.人源 CC 趋化因子受体 7 变构配体识别的结构基础。
Cell. 2019 Aug 22;178(5):1222-1230.e10. doi: 10.1016/j.cell.2019.07.028.
10
CXCR4 and CCR7 Expression in Primary Nodal Diffuse Large B-Cell Lymphoma-A Clinical and Immunohistochemical Study.原发结内弥漫大 B 细胞淋巴瘤中 CXCR4 和 CCR7 的表达：一项临床和免疫组化研究。
Am J Med Sci. 2019 Apr;357(4):302-310. doi: 10.1016/j.amjms.2019.01.008. Epub 2019 Jan 21.