Gómez J M, Aguilar M, Navarro M A, Ortolá J, Soler J
Endocrinology Laboratory Service, Ciudad Sanitaria y Universitaria de Bellvitge, Barcelona, Spain.
Clin Investig. 1994 Jul;72(7):489-93. doi: 10.1007/BF00207475.
We studied the growth hormone (GH) response to GH-releasing hormone (GHRH) and the thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) in four groups of patients with dementia and examined whether GH and TSH secretion is altered in patients with Alzheimer's disease. The four groups included those with Alzheimer's disease (n = 28), parkinsonism with dementia (n = 10), progressive supranuclear palsy with dementia (n = 10), and dementia of vascular origin (n = 28). The results showed no differences among the four groups in GH response to GHRH (12.2 +/- 2, 10.7 +/- 2, 8.9 +/- 1.1, and 9.9 +/- 1.9 micrograms/ml, respectively); there was no correlation between GH response to GHRH and sex, stage of the disease, or cerebral atrophy. The proportion of patients with exaggerated, normal, or lower GH response was similar in the four groups in terms of TSH response to TRH (9.2 +/- 0.9, 11.1 +/- 1, 11.1 +/- 1, and 10.3 +/- 1 mU/ml, respectively), nor was there a correlation between TSH response to TRH and sex, stage of the disease, cerebral atrophy, or GH response to GHRH. The proportion of those with exaggerated, normal, or lower TSH response was similar in the four groups. Cerebrospinal somatostatin levels were similar in Alzheimer's disease and vascular dementia patients. These findings indicate that neither GH response to GHRH nor TSH response to TRH provides a useful diagnostic adjunct in Alzheimer's disease patients.
我们研究了四组痴呆患者对生长激素释放激素（GHRH）的生长激素（GH）反应以及对促甲状腺激素释放激素（TRH）的促甲状腺激素（TSH）反应，并检查了阿尔茨海默病患者的GH和TSH分泌是否发生改变。这四组患者包括阿尔茨海默病患者（n = 28）、帕金森病合并痴呆患者（n = 10）、进行性核上性麻痹合并痴呆患者（n = 10）以及血管性痴呆患者（n = 28）。结果显示，四组患者对GHRH的GH反应无差异（分别为12.2±2、10.7±2、8.9±1.1和9.9±1.9微克/毫升）；对GHRH的GH反应与性别、疾病阶段或脑萎缩之间无相关性。就对TRH的TSH反应而言（分别为9.2±0.9、11.1±1、十一.1±1和10.3±1毫国际单位/毫升），四组中GH反应增强、正常或降低的患者比例相似。对TRH的TSH反应与性别、疾病阶段、脑萎缩或对GHRH的GH反应之间也无相关性。四组中TSH反应增强、正常或降低的患者比例相似。阿尔茨海默病患者和血管性痴呆患者的脑脊液生长抑素水平相似。这些发现表明，对GHRH的GH反应和对TRH的TSH反应均不能为阿尔茨海默病患者提供有用的辅助诊断方法。
