Perry E K, Blessed G, Tomlinson B E, Perry R H, Crow T J, Cross A J, Dockray G J, Dimaline R, Arregui A
Neurobiol Aging. 1981 Winter;2(4):251-6. doi: 10.1016/0197-4580(81)90032-4.
Activities relating to 3 neurotransmitter and 4 neuropeptide systems have been examined in human temporal lobe (post mortem) for their relationships with age and Alzheimer-type changes (senile plaques and cognitive function). Significant alterations with increasing age (from 61 to 92 years) in a series of non-demented cases included a reduction of the cholinergic enzyme, choline acetyltransferase, and an increase in vasoactive intestinal peptide immunoreactivity. In cases of alzheimer's disease the only neurochemical activity investigated which correlated significantly with cognitive impairment (assessed from a Mental Test Score obtained shortly before death) and with the severity of Alzheimer-type abnormalities (senile plaques density) was choline acetyltransferase. Further analyses of the data in relation to the severity of plaque formation suggest that alterations in other neurochemical activities including reductions in dopamine-beta-hydroxylase activity, cholecystokinin octapeptide (aqueous extracted) and somatostatin immunoreactivities and an increase in substance P immunoreactivity, may occur at later stages of the disease process. These comparative data suggest that biochemical changes in this brain area associated with age and earlier stages of Alzheimer's disease may be relatively selective.
在人类颞叶（尸检）中，对与3种神经递质和4种神经肽系统相关的活动进行了研究，以探讨它们与年龄及阿尔茨海默病类型变化（老年斑和认知功能）之间的关系。在一系列非痴呆病例中，随着年龄增长（从61岁至92岁）出现的显著变化包括胆碱能酶胆碱乙酰转移酶减少，以及血管活性肠肽免疫反应性增加。在阿尔茨海默病病例中，唯一与认知障碍（根据死亡前不久获得的心理测试分数评估）及阿尔茨海默病类型异常的严重程度（老年斑密度）显著相关的神经化学活动是胆碱乙酰转移酶。与斑块形成严重程度相关的数据的进一步分析表明，在疾病进程的后期阶段，可能会出现其他神经化学活动的改变，包括多巴胺-β-羟化酶活性降低、八肽胆囊收缩素（水提取物）和生长抑素免疫反应性降低以及P物质免疫反应性增加。这些比较数据表明，该脑区与年龄及阿尔茨海默病早期阶段相关的生化变化可能具有相对选择性。
