Schwartzman R A, Cidlowski J A
Department of Embryology, Carnegie Institution of Washington.
Int Arch Allergy Immunol. 1994 Dec;105(4):347-54. doi: 10.1159/000236781.
The induction of cell death in lymphoid cells by glucocorticoids is one of the earliest and most thoroughly studied models of apoptosis. Although the exact mechanism by which apoptosis occurs in lymphocytes is unknown many biochemical and molecular changes have been shown to occur in these cells in response to glucocorticoids. The role of chromatin degradation and endonucleases in the apoptotic process has been closely studied, as well as the involvement of several oncogenes in glucocorticoid-induced cell lysis. In addition, the clinical importance of glucocorticoid-induced apoptosis in the treatment of lymphoid neoplasms has recently received increased attention.
糖皮质激素诱导淋巴细胞死亡是最早且研究最深入的细胞凋亡模型之一。尽管淋巴细胞凋亡的确切机制尚不清楚，但已表明这些细胞在受到糖皮质激素作用时会发生许多生化和分子变化。染色质降解和核酸内切酶在凋亡过程中的作用已得到深入研究，同时也研究了几种癌基因在糖皮质激素诱导的细胞裂解中的作用。此外，糖皮质激素诱导的凋亡在淋巴瘤治疗中的临床重要性最近受到了更多关注。
