Lewis L M, Stothert J C, Gomez C R, Ruoff B E, Hall I S, Chandel B, Standeven J
Department of Neurology, Saint Louis University Health Sciences Center, Missouri.
J Crit Care. 1994 Sep;9(3):169-74. doi: 10.1016/0883-9441(94)90013-2.
This study evaluates the use of transcranial Doppler (TCD) ultrasound in assessing the changes experienced by the cerebral circulation during cardiopulmonary resuscitation (CPR) and compares it with measurements of internal carotid artery (ICA) flow rates (ultrasonic flow-meter measurements) and cerebral blood flow (CBF) (radioactive-microsphere measurements) in a porcine cardiac arrest model undergoing closed chest CPR.
Sixteen piglets were anesthetized and subjected to TCD monitoring, ICA flow-rate measurements, and CBF measurements during CPR following induction of ventricular fibrillation. A total of 14 comparisons between TCD and CBF measurements, and 36 comparisons between TCD and ICA flow measurements were performed. Correlations were determined using Pearson's method, and the validity of the correlation was determined using Bonferoni's adjusted probabilities.
The correlation between mean cerebral blood flow velocity and mean total ICA flow rate was 0.67 (P < .01). The correlation between peak systolic blood flow velocity and CBF was 0.76 (P = .02).
TCD can provide on-line information about cerebral perfusion during CPR.
本研究评估经颅多普勒（TCD）超声在评估心肺复苏（CPR）期间脑循环变化中的应用，并将其与在进行闭胸CPR的猪心脏骤停模型中颈内动脉（ICA）流速测量值（超声流量计测量）和脑血流量（CBF）（放射性微球测量）进行比较。
16只仔猪在诱导室颤后进行CPR期间接受麻醉，并接受TCD监测、ICA流速测量和CBF测量。TCD与CBF测量之间共进行了14次比较，TCD与ICA流量测量之间进行了36次比较。使用Pearson方法确定相关性，并使用Bonferroni调整概率确定相关性的有效性。
平均脑血流速度与平均总ICA流速之间的相关性为0.67（P <.01）。收缩期峰值血流速度与CBF之间的相关性为0.76（P =.02）。
TCD可提供CPR期间脑灌注的在线信息。
