Elinder L S, Walldius G
King Gustaf V Research Institute, Karolinska Institute, Stockholm, Sweden.
Curr Opin Lipidol. 1994 Aug;5(4):265-8. doi: 10.1097/00041433-199408000-00004.
In animal studies antioxidants have demonstrated antiatherosclerotic actions, but hitherto not in human studies. Prospective epidemiological data suggest that high doses of vitamin E have beneficial effects on major coronary heart disease. Unresolved questions concerning the role of LDL oxidation and antioxidants in atherosclerosis are discussed. It remains to be shown if antioxidants can retard lesion progression in humans, and by what mechanisms they are acting.
在动物研究中，抗氧化剂已显示出抗动脉粥样硬化作用，但迄今为止在人体研究中尚未得到证实。前瞻性流行病学数据表明，高剂量的维生素E对主要冠心病具有有益作用。文中讨论了有关低密度脂蛋白氧化和抗氧化剂在动脉粥样硬化中的作用的未解决问题。抗氧化剂是否能延缓人类病变进展以及它们通过何种机制发挥作用仍有待证实。
