Mechanisms of persistence of mycobacteria.

Pathogenic mycobacteria use a variety of mechanisms to survive and replicate within mononuclear phagocytic cells, including avoidance of early direct activation of macrophages, interference with gamma-interferon-mediated activation and inhibition of bactericidal products. Developments in genetic manipulation should allow the genes involved in mycobacterial virulence and intracellular survival to be identified. Understanding these mechanisms may lead to more effective treatment and prevention of mycobacterial infections.