Shimizu N, Nakane H, Hori T, Hayashi Y
Department of Chemistry and Chemical Engineering, Kanazawa University, Japan.
Brain Res. 1994 Aug 15;654(1):145-8. doi: 10.1016/0006-8993(94)91580-6.
Noradrenaline release in rat medial prefrontal cortex (PFC) was measured using a brain microdialysis technique. Immobilization stress increased noradrenaline release to a maximum level of 248.7 +/- 12.8% of the basal release, which was significantly attenuated by preinjection of alpha-helical CRF9-41 (50 micrograms/rat) into the lateral cerebroventricle. Intracerebroventricular injection of CRF also increased noradrenaline release in the medial PFC. These results suggest that immobilization-stress facilitates noradrenaline release in the medial PFC through activation of the CRF system in the brain.
采用脑微透析技术测定大鼠内侧前额叶皮质（PFC）中去甲肾上腺素的释放。束缚应激使去甲肾上腺素释放增加至基础释放量的248.7 +/- 12.8%的最高水平，预先向侧脑室注射α-螺旋CRF9-41（50微克/大鼠）可显著减弱这一效应。脑室内注射CRF也可增加内侧PFC中去甲肾上腺素的释放。这些结果表明，束缚应激通过激活脑中的CRF系统促进内侧PFC中去甲肾上腺素的释放。
