Emoto H, Koga C, Ishii H, Yokoo H, Yoshida M, Tanaka M
Department of Pharmacology, Kurume University School of Medicine, Japan.
Yakubutsu Seishin Kodo. 1993 Apr;13(2):81-7.
We investigated the effects of intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor (CRF) antagonist, alpha-helical CRF9-41 (ahCRF) on stress-induced increases in noradrenaline (NA) release in rat brain regions. Pretreatment with ahCRF (50 or 100 micrograms) attenuated significantly the stress-induced increases in levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4), the major metabolite of NA in rat brain, in the locus coeruleus region, cerebral cortex, hippocampus, amygdala and hypothalamus. Plasma corticosterone levels were not decreased significantly by administration of ahCRF. From these results, it is suggested that stress-induced increases in NA release in the rat brain regions are attenuated by ahCRF and thus that CRF, released during the stress, cause increases in NA release in these regions.
我们研究了脑室内（i.c.v.）注射促肾上腺皮质激素释放因子（CRF）拮抗剂α-螺旋CRF9-41（ahCRF）对大鼠脑区应激诱导的去甲肾上腺素（NA）释放增加的影响。用ahCRF（50或100微克）预处理可显著减弱应激诱导的大鼠脑蓝斑区域、大脑皮层、海马、杏仁核和下丘脑3-甲氧基-4-羟基苯乙二醇硫酸盐（MHPG-SO4，NA在大鼠脑中的主要代谢产物）水平的增加。给予ahCRF后，血浆皮质酮水平未显著降低。从这些结果来看，提示ahCRF可减弱应激诱导的大鼠脑区NA释放增加，因此应激期间释放的CRF可导致这些区域NA释放增加。
