Chen C C, Lirng J F, Chou Y H, Teng M H, Shen W C, Lee S K, Chang T
Department of Radiology, Taichung Veterans General Hospital, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1994 Oct;54(4):251-8.
Although surgical endarterectomy or bypass is regarded as the treatment-of-choice for extracranial cerebral vascular stenosis, percutaneous transluminal angioplasty (PTA) has its role as an alternative procedure for symptomatic patients refractory to medical therapy and/or for whom surgical treatment is contraindicated.
Occlusive blood vessels were first identified by neurologic, ultrasonic and angiographic studies. Patients were premedicated with heparin and corticosteroid. From a transfemoral approach, double lumen balloon dilatation catheter was guided across the area of stenosis, and inflated two or three times to produce dilatation. Following PTA, patients received anticoagulants and corticosteroid for a period, and were followed by clinical examination, Doppler blood-flow and angiographic studies.
Seventeen patients undergoing 26 procedures were included in this study. The lesions involved subclavian artery in nine cases, common carotid artery in seven, internal carotid artery in five and proximal vertebral artery in five. Digital subtraction angiography (DSA) was done immediately after PTA and showed improvement of stenotic segment (residual stenosis < 30%) in 22 vessels. Restenosis occurred in two cases of subclavian artery PTA six months later. There were three complications, including TIA in two cases and hematoma at the puncture site in one case. Clinically, symptomatic improvement was obtained in 13 cases.
In patients with significant atherosclerotic stenosis of neck vessels, PTA is a beneficial procedure for improving blood flow to brain circulation and for alleviating symptoms.
尽管外科动脉内膜切除术或搭桥术被视为颅外脑血管狭窄的首选治疗方法,但经皮腔内血管成形术(PTA)对于药物治疗无效和/或手术治疗禁忌的有症状患者而言,可作为一种替代治疗手段。
首先通过神经学、超声和血管造影研究确定闭塞血管。患者术前给予肝素和皮质类固醇进行预处理。经股动脉途径,将双腔球囊扩张导管引导穿过狭窄区域,并充气两到三次以进行扩张。PTA术后,患者接受一段时间的抗凝剂和皮质类固醇治疗,随后进行临床检查、多普勒血流检查和血管造影研究。
本研究纳入了17例接受26次手术的患者。病变累及锁骨下动脉9例、颈总动脉7例、颈内动脉5例和椎动脉近端5例。PTA术后立即进行数字减影血管造影(DSA),结果显示22条血管的狭窄段有所改善(残余狭窄<30%)。锁骨下动脉PTA术后6个月,有2例发生再狭窄。发生了3例并发症,包括2例短暂性脑缺血发作和1例穿刺部位血肿。临床上,13例患者症状得到改善。
对于颈部血管存在明显动脉粥样硬化狭窄的患者,PTA是改善脑循环血流和缓解症状的有益治疗方法。