Matsuda T, Takada N, Yano Y, Wanibuchi H, Otani S, Fukushima S
First Department of Pathology, Osaka City University Medical School, Japan.
Cancer Lett. 1994 Nov 11;86(2):229-34. doi: 10.1016/0304-3835(94)90083-3.
Two organosulfur compounds, methyl propyl disulfide (MPD) and propylene sulfide (PS) from garlic and onions, were studied for their modifying effects on hepatocarcinogenesis in the F344 rats. Modifying potential was scored by comparing the number and area per cm2 of induced glutathione S-transferase placental form (GST-P)-positive foci in the liver. MPD and PS significantly reduced both these parameters of GST-P-positive foci in a dose-dependent manner. To investigate possible mechanisms of inhibition, ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) activities were measured. In MPD and PS-high dose-treated liver tissue there was a tendency for their decrease, albeit non-significant, which suggested that the inhibitory effect might have been caused by decreased cell proliferation associated with decreased polyamine biosynthesis. In evaluating relationships between diet and cancer, it is thus necessary to consider various effects in assessing possible protective roles of garlic and onions.
研究了来自大蒜和洋葱的两种有机硫化合物——甲基丙基二硫化物（MPD）和硫化丙烯（PS）对F344大鼠肝癌发生的修饰作用。通过比较肝脏中诱导型谷胱甘肽S-转移酶胎盘型（GST-P）阳性灶每平方厘米的数量和面积来评估修饰潜力。MPD和PS以剂量依赖性方式显著降低了GST-P阳性灶的这两个参数。为了研究可能的抑制机制，测量了鸟氨酸脱羧酶（ODC）和亚精胺/精胺N1-乙酰转移酶（SAT）的活性。在MPD和PS高剂量处理的肝组织中，它们有下降的趋势，尽管不显著，这表明抑制作用可能是由于与多胺生物合成减少相关的细胞增殖减少所致。因此，在评估饮食与癌症之间的关系时，有必要在评估大蒜和洋葱可能的保护作用时考虑各种影响。
