Sparnins V L, Barany G, Wattenberg L W
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.
Carcinogenesis. 1988 Jan;9(1):131-4. doi: 10.1093/carcin/9.1.131.
In the present study, eight organosulfur compounds from garlic and onions were studied for their inhibitory effects on benzo[a]pyrene (BP)-induced neoplasia of forestomach and lung of female A/J mice when administered 96 and 48 h prior to carcinogen challenge. These compounds had one, two or three linearly connected sulfur atoms. They included the four allyl group-containing derivatives: allyl methyl trisulfide (AMT), allyl methyl disulfide (AMD), diallyl trisulfide (DAT), and diallyl sulfide (DAS), and also four corresponding saturated compounds in which propyl groups were substituted for the allyl groups. All four allylic compounds inhibited BP-induced neoplasia of the forestomach. The saturated analogs were almost without inhibitory activity, indicating the importance of the allyl groups. DAT, which contains two allyl groups, was more potent than AMT, which contains only one allyl group, thus providing further evidence for the role of allyl groups in the inhibitory effects observed. DAS and AMD, but not DAT or AMT, inhibited pulmonary adenoma formation. The fact that in the lung the monosulfide and disulfide inhibited, but the trisulfide did not inhibit, indicates that the number of sulfur atoms in the molecule can control the organ sites at which protection against carcinogenesis will occur. All four allylic compounds induced increased glutathione S-transferase (GST) activity in the forestomach, but varied in their capacity to induce GST in lung, liver and small bowel. Their saturated analogs produced little or no induction. In evaluating relationships between diet and cancer, it would be useful to consider the possible role of garlic and onion organosulfur compounds as protective agents. In addition, further studies of this class of chemicals might lead to the identification and development of useful new chemopreventive compounds.
在本研究中，对大蒜和洋葱中的八种有机硫化合物进行了研究，观察它们在致癌物攻击前96小时和48小时给予雌性A/J小鼠时，对苯并[a]芘（BP）诱导的前胃和肺肿瘤形成的抑制作用。这些化合物含有一个、两个或三个线性连接的硫原子。它们包括四种含烯丙基的衍生物：烯丙基甲基三硫醚（AMT）、烯丙基甲基二硫醚（AMD）、二烯丙基三硫醚（DAT）和二烯丙基硫醚（DAS），以及四种相应的饱和化合物，其中丙基取代了烯丙基。所有四种烯丙基化合物均抑制BP诱导的前胃肿瘤形成。饱和类似物几乎没有抑制活性，表明烯丙基的重要性。含有两个烯丙基的DAT比仅含有一个烯丙基的AMT更有效，从而为烯丙基在观察到的抑制作用中的作用提供了进一步证据。DAS和AMD，但不是DAT或AMT，抑制肺腺瘤形成。在肺中，一硫化物和二硫化物有抑制作用，但三硫化物没有抑制作用，这一事实表明分子中的硫原子数量可以控制发生抗癌保护作用的器官部位。所有四种烯丙基化合物均诱导前胃中谷胱甘肽S-转移酶（GST）活性增加，但它们在肺、肝和小肠中诱导GST的能力有所不同。它们的饱和类似物几乎没有或没有诱导作用。在评估饮食与癌症之间的关系时，考虑大蒜和洋葱有机硫化合物作为保护剂的可能作用将是有益的。此外，对这类化学物质的进一步研究可能会导致识别和开发有用的新型化学预防化合物。
