Jelinek T, Ziegler M, Löscher T
Abteilung für Infektions- und Tropenmedizin, Medizinische Klinik Innenstadt, Universität München.
Dtsch Med Wochenschr. 1994 Nov 25;119(47):1618-22. doi: 10.1055/s-2008-1058879.
During a 4-week holiday in Thailand a 13-year-old boy from Germany briefly fell ill with diarrhoea without blood-tinged stools and fever. 5 months later oedematous, reddish swellings occurred, at first on the right upper arm, later over the right side of the chest. Especially at night these swellings were associated with severe local and generalized itching. Bilaterally the axillary lymph-nodes were hard and slightly enlarged. There was a marked eosinophilia of 56%, the white count was 22,700/microliters and the serum level of IgE was raised to 1777 IU/ml. No worm eggs or larvae were found in the stool. Enzyme-linked immunosorbent assay, using larvae of Gnathostoma spinigerum as antigen, demonstrated antibodies against this nematode. Gnathostomiasis having been diagnosed treatment was started with albendazole (200 mg twice daily for 21 days), after which the boy was symptom free. After 2 months the eosinophilia had regressed to 10%, the white cell count was normal and the antibody titre had fallen.
一名来自德国的13岁男孩在泰国度过4周假期期间，曾短暂患腹泻，粪便无血便且无发热症状。5个月后，出现水肿性、微红肿胀，起初出现在右上臂，后来蔓延至胸部右侧。尤其是在夜间，这些肿胀伴有严重的局部和全身瘙痒。双侧腋窝淋巴结坚硬且稍有肿大。嗜酸性粒细胞显著增多，达56%，白细胞计数为22,700/微升，血清IgE水平升至1777 IU/ml。粪便中未发现虫卵或幼虫。以棘颚口线虫幼虫为抗原进行酶联免疫吸附测定，结果显示存在针对这种线虫的抗体。诊断为颚口线虫病后，开始使用阿苯达唑治疗（每日2次，每次200毫克，共21天），之后男孩症状消失。2个月后，嗜酸性粒细胞增多症消退至10%，白细胞计数正常，抗体滴度下降。
