Fujii Y, Gonoi T, Yamada Y, Chihara K, Inagaki N, Seino S
Division of Molecular Medicine, Chiba University School of Medicine, Japan.
FEBS Lett. 1994 Nov 28;355(2):117-20. doi: 10.1016/0014-5793(94)01159-1.
Somatostatin and its analogue SMS 201-995 inhibit high voltage-activated (HVA) Ca2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2). In contrast, neither somatostatin nor SMS 201-995 suppresses the HVA Ca2+ currents in RINm5F which stably express cloned hSSTR1. These results suggest that somatostatin-induced inhibition of HVA Ca2+ currents is mediated by a specific receptor subtype and that inhibition of calcium influx through HVA Ca2+ channels is one of the mechanisms of SMS 201-995 action on inhibitory processes of hormone secretion and cell proliferation.
