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Molecular pharmacology of somatostatin receptor subtypes.

作者信息

Patel Y C

机构信息

Fraser Laboratories, McGill University, Department of Medicine, Montreal, Quebec, Canada.

出版信息

J Endocrinol Invest. 1997 Jun;20(6):348-67. doi: 10.1007/BF03350317.

DOI:10.1007/BF03350317
PMID:9294784
Abstract
摘要

相似文献

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Molecular pharmacology of somatostatin receptor subtypes.生长抑素受体亚型的分子药理学
J Endocrinol Invest. 1997 Jun;20(6):348-67. doi: 10.1007/BF03350317.
2
Somatostatin and its receptor family.生长抑素及其受体家族。
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Somatostatin receptor activation of cellular effector systems.
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Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.位于20号染色体上的人促生长激素抑制素-14选择性受体变体（促生长激素抑制素受体4）的克隆与表达。
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Molecular pharmacology of somatostatin-receptor subtypes.
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[Molecular biology, pharmacology and signal transduction of 5 cloned human somatostatin receptors].[5种克隆的人类生长抑素受体的分子生物学、药理学及信号转导]
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Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.对生长抑素-28具有优先亲和力的人类生长抑素受体（5型生长抑素受体）的分子克隆、功能特性及染色体定位
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International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature.国际基础和临床药理学联合会。生长抑素受体：结构、功能、配体和新命名。
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Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.生长抑素受体亚型2中第89位残基处的天冬氨酸突变可阻止Na⁺对激动剂结合的调节，但不改变受体与G蛋白的结合。
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本文引用的文献

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Ligand binding pocket of the human somatostatin receptor 5: mutational analysis of the extracellular domains.
Mol Pharmacol. 1997 Nov;52(5):807-14. doi: 10.1124/mol.52.5.807.
2
Identification and characterization of a novel human cortistatin-like peptide.
Biochem Biophys Res Commun. 1997 Mar 6;232(1):157-63. doi: 10.1006/bbrc.1997.6252.
3
17-beta-estradiol-dependent regulation of somatostatin receptor subtype expression in the 7315b prolactin secreting rat pituitary tumor in vitro and in vivo.17-β-雌二醇对7315b分泌催乳素的大鼠垂体瘤中生长抑素受体亚型表达的体内外依赖性调节
Endocrinology. 1997 Mar;138(3):1180-9. doi: 10.1210/endo.138.3.5016.
4
肽类疗法：探索抗癌潜力——穿越1989年的历程
Cancers (Basel). 2024 Mar 2;16(5):1032. doi: 10.3390/cancers16051032.
4
Somatostatin and Somatostatin Receptors in Tumour Biology.生长抑素及其受体在肿瘤生物学中的作用。
Int J Mol Sci. 2023 Dec 28;25(1):436. doi: 10.3390/ijms25010436.
5
The Role of Receptor-Ligand Interaction in Somatostatin Signaling Pathways: Implications for Neuroendocrine Tumors.受体-配体相互作用在生长抑素信号通路中的作用：对神经内分泌肿瘤的影响
Cancers (Basel). 2023 Dec 25;16(1):116. doi: 10.3390/cancers16010116.
6
A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism.一种选择性非肽类生长抑素受体 5 激动剂可有效降低高胰岛素血症中的胰岛素分泌。
J Biol Chem. 2023 Jun;299(6):104816. doi: 10.1016/j.jbc.2023.104816. Epub 2023 May 11.
7
Synthesis, Antiproliferative Effect and In Silico LogP Prediction of BIM-23052 Analogs Containing Tyr Instead of Phe.含酪氨酸而非苯丙氨酸的BIM-23052类似物的合成、抗增殖作用及计算机辅助LogP预测
Pharmaceutics. 2023 Mar 31;15(4):1123. doi: 10.3390/pharmaceutics15041123.
8
Immunomodulatory Role of Neuropeptides in the Cornea.神经肽在角膜中的免疫调节作用。
Biomedicines. 2022 Aug 16;10(8):1985. doi: 10.3390/biomedicines10081985.
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Effect of Obesity on the Expression of Nutrient Receptors and Satiety Hormones in the Human Colon.肥胖对人类结肠中营养受体和饱腹感激素表达的影响。
Nutrients. 2021 Apr 13;13(4):1271. doi: 10.3390/nu13041271.
10
Expression of Somatostatin Receptor Subtypes (SSTR-1-SSTR-5) in Pediatric Hematological and Oncological Disorders.生长抑素受体亚型（SSTR-1-SSTR-5）在儿科血液和肿瘤疾病中的表达。
Molecules. 2020 Dec 7;25(23):5775. doi: 10.3390/molecules25235775.
Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.人胎儿垂体培养物中生长抑素受体亚型的特异性。SSTR2和SSTR5在生长激素、促甲状腺激素及催乳素调节中的不同作用。
J Clin Invest. 1997 Feb 15;99(4):789-98. doi: 10.1172/JCI119225.
5
Endocytosis of the rat somatostatin receptors: subtype discrimination, ligand specificity, and delineation of carboxy-terminal positive and negative sequence motifs.大鼠生长抑素受体的内吞作用：亚型鉴别、配体特异性以及羧基末端正负序列基序的描绘。
DNA Cell Biol. 1997 Jan;16(1):111-9. doi: 10.1089/dna.1997.16.111.
6
Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1.发现一个位于1号染色体上的新型人类G蛋白偶联受体基因（GPR25）。
Biochem Biophys Res Commun. 1997 Jan 3;230(1):69-72. doi: 10.1006/bbrc.1996.5828.
7
Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis.肾囊肿细胞中16号染色体短臂1区3带的多囊肾病（PKD1）区域缺失支持了囊肿发病机制的功能丧失模型。
J Clin Invest. 1997 Jan 15;99(2):194-9. doi: 10.1172/JCI119147.
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Coexistence of somatostatin receptor subtypes in the human neuroblastoma cell line LA-N-2.
FEBS Lett. 1997 Jan 13;401(1):83-8. doi: 10.1016/s0014-5793(96)01441-x.
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Thyroid hormone-induced expression of specific somatostatin receptor subtypes correlates with involution of the TtT-97 murine thyrotrope tumor.
Endocrinology. 1997 Feb;138(2):719-24. doi: 10.1210/endo.138.2.4951.
10
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EMBO J. 1996 Dec 2;15(23):6680-90.