Tajima K, Katagiri T
Department of Internal Medicine, Yamagata Prefectural Kahoku Hospital, Japan.
Dig Dis Sci. 1996 Feb;41(2):282-8. doi: 10.1007/BF02093816.
A case of hypereosinophilic syndrome with eosinophilic colitis, eosinophilic cholecystitis, and increased serum levels of interleukin-5 (IL-5) and soluble interleukin-2 receptor (sIL-2R) is reported. Immunohistochemical studies of cholecystectomy and colon biopsy specimens with monoclonal antibodies, which are specific for activated eosinophils, secreted eosinophil cationic protein (ECP) and for major basic protein (MBP), demonstrated the presence of numerous activated eosinophils, secretion of ECP, and deposition of MBP in areas of tissue damage. These findings suggest that in eosinophilic cholecystitis and eosinophilic colitis, activated eosinophils infiltrate and degranulate in each tissue, releasing eosinophil granule proteins that produce tissue damage.
本文报道了一例伴有嗜酸性粒细胞性结肠炎、嗜酸性粒细胞性胆囊炎以及血清白细胞介素-5（IL-5）和可溶性白细胞介素-2受体（sIL-2R）水平升高的高嗜酸性粒细胞综合征病例。使用针对活化嗜酸性粒细胞、分泌型嗜酸性粒细胞阳离子蛋白（ECP）以及主要碱性蛋白（MBP）的单克隆抗体，对胆囊切除术和结肠活检标本进行免疫组织化学研究，结果显示在组织损伤区域存在大量活化嗜酸性粒细胞、ECP的分泌以及MBP的沉积。这些发现表明，在嗜酸性粒细胞性胆囊炎和嗜酸性粒细胞性结肠炎中，活化嗜酸性粒细胞浸润并在每个组织中脱颗粒，释放出导致组织损伤的嗜酸性粒细胞颗粒蛋白。
