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Lanthanide ions for the first non-enzymatic formation of adenosine 3',5'-cyclic monophosphate from adenosine triphosphate under physiological conditions.

作者信息

Yajima H, Sumaoka J, Miyama S, Komiyama M

机构信息

Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo.

出版信息

J Biochem. 1994 Jun;115(6):1038-9. doi: 10.1093/oxfordjournals.jbchem.a124453.

DOI:10.1093/oxfordjournals.jbchem.a124453
PMID:7982878
Abstract

Adenosine 3',5'-cyclic monophosphate (cAMP) is formed from adenosine triphosphate at pH 8 and 50 degrees C by use of lanthanide ions. Pr3+ and La3+ are the most active. The cAMP formation is more efficient at higher pH, where the mixture is made homogeneous by the addition of beta-cyclodextrin. The potential functioning of lanthanide ions as the catalytic center of an artificial adenylate cyclase is indicated.

摘要

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