胰岛素和低血糖对人体听觉脑干反应的影响。

Effects of insulin and hypoglycemia on the auditory brain stem response in humans.

Kern W, Kerner W, Pietrowsky R, Fehm H L, Born J

Department of Clinical Neuroendocrinology, University of Lübeck, Germany.

J Neurophysiol. 1994 Aug;72(2):678-83. doi: 10.1152/jn.1994.72.2.678.

Abstract

This study aimed to differentiate effects of insulin and hypoglycemia on sensory brain stem functions in humans. Auditory brain stem responses (ABR) were examined in 30 healthy men during euglycemia and after 20 and 50 min of steady-state hypoglycemia of 2.6 mM induced with human insulin (HI) in one session and porcine insulin (PI) in another session. 2. Levels of blood glucose and serum insulin were identical in both sessions during HI and PI infusion. 3. Hypoglycemia increased interpeak latencies III-V (+71 microseconds; P < 0.001) and I-V (+123 microseconds; P < 0.001), whereas changes in the latency of wave I were not significant. 4. After 20 min of constant hypoglycemia, increases in the interpeak latencies I-V and III-V were significantly more pronounced during infusion of PI than HI. These differences disappeared with time spent in hypoglycemia, i.e., after 50 min of hypoglycemia. 5. Apart from the delaying effect of hypoglycemia on neuronal transmission within the sensory brain stem, the results provide evidence for a separate influence of insulin on these functions.

摘要

本研究旨在区分胰岛素和低血糖对人体感觉脑干功能的影响。在30名健康男性中，于血糖正常时以及在一次使用人胰岛素（HI）、另一次使用猪胰岛素（PI）诱导的2.6 mM稳态低血糖20分钟和50分钟后，检测听觉脑干反应（ABR）。2. 在HI和PI输注期间，两个阶段的血糖水平和血清胰岛素水平相同。3. 低血糖使峰间潜伏期III-V增加（+71微秒；P<0.001）和I-V增加（+123微秒；P<0.001），而波I潜伏期的变化不显著。4. 在持续低血糖20分钟后，PI输注期间峰间潜伏期I-V和III-V的增加明显比HI更显著。随着低血糖持续时间的延长，即低血糖50分钟后，这些差异消失。5. 除了低血糖对感觉脑干内神经元传递的延迟作用外，结果还证明胰岛素对这些功能有单独影响。