Satoh M, Ajmani A K, Hirakata M, Suwa A, Winfield J B, Reeves W H
Department of Medicine, University of North Carolina at Chapel Hill 27599-7280.
J Rheumatol. 1994 Aug;21(8):1564-6.
A 24-year-old black woman developed polymyositis with autoantibodies to threonyl-tRNA synthetase in the 2nd trimester of her 3rd pregnancy. This was complicated by fetal loss and the development of severe relapsing myositis resistant to corticosteroid and azathioprine therapy. These features were also common in other cases in the literature. Antisynthetase antibodies had not been reported in myositis occurring during pregnancy and may be of interest regarding the pathogenesis of inflammatory myopathy complicating pregnancy.
一名24岁的黑人女性在第三次怀孕的孕中期患上了伴有抗苏氨酰-tRNA合成酶自身抗体的多发性肌炎。这引发了胎儿丢失，并出现了对皮质类固醇和硫唑嘌呤治疗耐药的严重复发性肌炎。这些特征在文献中的其他病例中也很常见。抗合成酶抗体在妊娠期间发生的肌炎中尚未见报道，对于妊娠合并炎症性肌病的发病机制可能具有重要意义。
